BRENDA - Enzyme Database show
show all sequences of 3.5.1.19

Nicotinamidase activity is important for germination

Hunt, L.; Holdsworth, M.J.; Gray, J.E.; Plant J. 51, 341-351 (2007)

Data extracted from this reference:

Activating Compound
Activating Compound
Commentary
Organism
Structure
DTT
-
Arabidopsis thaliana
MgCl2
-
Arabidopsis thaliana
Cloned(Commentary)
Commentary
Organism
expression in Escherichia coli
Arabidopsis thaliana
Inhibitors
Inhibitors
Commentary
Organism
Structure
CuCl2
-
Arabidopsis thaliana
NiCl2
-
Arabidopsis thaliana
ZnCl2
-
Arabidopsis thaliana
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
nicotinamide + H2O
Arabidopsis thaliana
as nicotinamide is an inhibitor of Arabidopsis seed germination, enzyme activity is important for germination
nicotinic acid + NH3
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Arabidopsis thaliana
-
-
-
Purification (Commentary)
Commentary
Organism
nickel-based affinity chromatography
Arabidopsis thaliana
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
nicotinamide + H2O
as nicotinamide is an inhibitor of Arabidopsis seed germination, enzyme activity is important for germination
682380
Arabidopsis thaliana
nicotinic acid + NH3
-
-
-
?
Activating Compound (protein specific)
Activating Compound
Commentary
Organism
Structure
DTT
-
Arabidopsis thaliana
MgCl2
-
Arabidopsis thaliana
Cloned(Commentary) (protein specific)
Commentary
Organism
expression in Escherichia coli
Arabidopsis thaliana
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
CuCl2
-
Arabidopsis thaliana
NiCl2
-
Arabidopsis thaliana
ZnCl2
-
Arabidopsis thaliana
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
nicotinamide + H2O
Arabidopsis thaliana
as nicotinamide is an inhibitor of Arabidopsis seed germination, enzyme activity is important for germination
nicotinic acid + NH3
-
-
?
Purification (Commentary) (protein specific)
Commentary
Organism
nickel-based affinity chromatography
Arabidopsis thaliana
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
nicotinamide + H2O
as nicotinamide is an inhibitor of Arabidopsis seed germination, enzyme activity is important for germination
682380
Arabidopsis thaliana
nicotinic acid + NH3
-
-
-
?
Other publictions for EC 3.5.1.19
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
727053
Stekhanova
Nicotinamidase from the thermo ...
Acidilobus saccharovorans, Acidilobus saccharovorans DSM 16705
Biochemistry
79
54-61
2014
2
-
1
-
-
-
4
1
-
1
1
-
-
7
-
-
-
-
-
-
-
-
2
1
1
1
2
1
1
-
-
-
-
-
-
2
-
1
-
-
-
-
-
4
-
1
-
1
1
-
-
-
-
-
-
-
-
-
2
1
1
1
2
1
1
-
-
-
-
1
1
-
1
1
729184
Stekhanova
Nicotinamidase from the thermo ...
Acidilobus saccharovorans, Acidilobus saccharovorans DSM 16705
Biochemistry (Moscow)
79
54-61
2014
3
-
1
-
-
-
3
2
-
1
1
-
-
7
-
-
-
-
-
-
-
-
6
1
1
1
2
2
1
1
-
-
-
-
-
3
-
1
-
-
-
-
-
3
-
2
-
1
1
-
-
-
-
-
-
-
-
-
6
1
1
1
2
2
1
1
-
-
-
-
-
-
2
2
734741
Ion
A multi-scale computational st ...
Streptococcus pneumoniae
Molecules
19
15735-15753
2014
-
1
-
-
-
-
-
-
-
1
-
1
-
2
-
-
-
1
-
-
-
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2
-
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-
-
-
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-
-
-
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1
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-
-
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-
-
1
-
1
-
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-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
3
3
-
-
-
735324
Rueda
Nicotinamidase/pyrazinamidase ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Tuberculosis
94
644-648
2014
-
-
1
-
-
-
-
-
-
-
1
4
-
3
-
-
1
-
-
-
-
-
4
2
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
4
-
-
-
1
-
-
-
-
4
2
-
-
-
-
-
-
-
-
-
1
1
-
-
-
735084
Sanchez-Carron
Biochemical and mutational ana ...
Oceanobacillus iheyensis, Oceanobacillus iheyensis HTE831
PLoS ONE
8
e56727
2013
-
-
1
-
9
-
2
27
-
2
2
4
-
5
-
-
1
-
-
-
28
-
12
1
1
1
1
26
1
1
1
-
2
-
-
-
-
1
-
-
9
-
-
2
2
27
-
2
2
4
-
-
-
1
-
-
28
-
12
1
1
1
1
26
1
1
1
-
-
2
2
-
26
26
718924
Smith
Structural and kinetic isotope ...
Saccharomyces cerevisiae
Biochemistry
51
243-256
2012
-
-
1
1
10
-
6
8
-
1
-
1
-
6
-
-
1
-
-
-
-
-
7
-
-
-
-
12
1
-
-
-
5
-
-
-
-
1
-
1
10
-
-
6
5
8
-
1
-
1
-
-
-
1
-
-
-
-
7
-
-
-
-
12
1
-
-
-
-
-
-
-
15
15
719619
Gazanion
Leishmania infantum nicotinami ...
Leishmania infantum
Int. J. Parasitol.
42
323-327
2012
-
-
-
-
1
-
-
-
-
-
-
1
-
5
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
735054
Zhang
Molecular dynamics simulations ...
Acinetobacter baumannii, Streptococcus pneumoniae
PLoS ONE
7
e39546
2012
-
-
-
2
-
-
-
-
-
-
-
4
-
3
-
-
-
-
-
-
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
6
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
720499
Gazanion
The Leishmania nicotinamidase ...
Leishmania infantum, Leishmania infantum MHOM/MA/67/ITMAP-263
Mol. Microbiol.
82
21-38
2011
-
-
1
1
1
-
-
-
1
-
2
4
-
7
-
-
1
-
-
1
-
-
4
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
1
-
-
-
-
-
1
-
2
4
-
-
-
1
-
1
-
-
4
1
-
-
-
-
-
-
-
-
-
2
2
-
-
-
718859
French
Characterization of nicotinami ...
Borreliella burgdorferi, Caenorhabditis elegans, Plasmodium falciparum, Saccharomyces cerevisiae, Streptococcus pneumoniae
Biochemistry
49
10421-10439
2010
-
-
5
-
4
-
46
6
-
-
-
45
-
17
-
-
5
-
-
-
-
-
45
-
-
-
-
6
-
-
-
-
32
-
-
-
-
5
-
-
4
-
-
46
32
6
-
-
-
45
-
-
-
5
-
-
-
-
45
-
-
-
-
6
-
-
-
-
-
5
5
-
-
-
718883
French
High-resolution crystal struct ...
Streptococcus pneumoniae
Biochemistry
49
8803-8812
2010
-
-
1
1
1
-
2
-
-
5
1
1
-
5
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
1
-
-
2
-
-
-
5
1
1
-
-
-
1
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
718885
Seiner
Kinetics and inhibition of nic ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Biochemistry
49
9613-9619
2010
-
-
1
-
1
-
4
4
-
2
-
4
-
162
-
-
1
-
-
-
-
-
4
-
-
-
-
4
1
-
-
-
2
-
-
-
-
1
-
-
1
-
-
4
2
4
-
2
-
4
-
-
-
1
-
-
-
-
4
-
-
-
-
4
1
-
-
-
-
1
1
-
4
4
710862
Fyfe
Specificity and mechanism of A ...
Acinetobacter baumannii
Angew. Chem. Int. Ed. Engl.
48
9176-9179
2009
-
-
-
-
-
-
-
-
-
4
1
2
-
2
-
-
-
1
-
-
-
-
3
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
4
1
2
-
-
-
-
-
-
-
-
3
1
-
-
-
-
-
-
-
-
-
2
2
-
-
-
711827
Vrablik
Nicotinamidase modulation of N ...
Caenorhabditis elegans
Development
136
3637-3646
2009
-
-
1
-
1
-
-
-
1
1
-
1
-
4
-
-
-
-
-
-
-
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
1
1
-
1
-
-
-
-
-
-
-
-
1
-
1
-
-
-
1
-
-
-
-
2
2
-
-
-
679806
Zhang
Characterization of Mycobacter ...
Mycobacterium tuberculosis
FEBS J.
275
753-762
2008
-
1
1
-
9
-
-
-
-
2
1
2
-
3
-
-
1
-
-
-
2
-
2
1
1
-
1
-
1
-
1
-
-
-
-
-
1
1
-
-
9
-
-
-
-
-
-
2
1
2
-
-
-
1
-
-
2
-
2
1
1
-
1
-
1
-
1
-
-
-
-
-
-
-
697513
Chong
Enhanced tolerance against ear ...
Drosophila melanogaster
Curr. Neurovasc. Res.
5
159-170
2008
-
-
1
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
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1
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-
-
-
698121
McClure
Pnc1p-mediated nicotinamide cl ...
Saccharomyces cerevisiae
Genetics
180
797-810
2008
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
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-
698815
Balan
Life span extension and neuron ...
Drosophila melanogaster
J. Biol. Chem.
283
27810-27819
2008
-
-
1
-
-
-
-
-
-
-
1
-
-
6
-
-
1
-
-
1
-
-
2
1
-
-
-
-
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-
-
-
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1
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1
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1
-
1
-
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2
1
-
-
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-
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-
700669
Yin
Changes in pyridine metabolism ...
Lotus japonicus
Phytochemistry
69
2891-2898
2008
-
-
-
-
-
-
-
-
-
-
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2
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1
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1
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677824
Hu
Crystal structure of the yeast ...
Saccharomyces cerevisiae
Arch. Biochem. Biophys.
461
66-75
2007
-
-
1
1
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1
-
1
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2
-
3
-
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1
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2
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2
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1
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1
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1
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1
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2
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1
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2
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2
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681746
van der Horst
The Caenorhabditis elegans nic ...
Caenorhabditis elegans
Mech. Ageing Dev.
128
346-349
2007
-
-
-
-
-
-
-
-
-
-
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1
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4
-
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1
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1
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1
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-
-
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-
682376
Wang
Nicotinamidase participates in ...
Arabidopsis thaliana
Plant J.
49
1020-1029
2007
-
-
-
-
-
-
-
1
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-
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1
-
6
-
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2
-
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1
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1
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1
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1
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2
-
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1
-
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-
-
1
-
-
-
-
-
-
-
-
-
-
682380
Hunt
Nicotinamidase activity is imp ...
Arabidopsis thaliana
Plant J.
51
341-351
2007
2
-
1
-
-
-
3
-
-
-
-
1
-
3
-
-
1
-
-
-
-
-
1
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2
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1
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3
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1
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1
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1
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659608
Zheng
Changes in trigonelline (N-met ...
Vigna radiata var. radiata
J. Exp. Bot.
56
1615-1623
2005
-
-
-
-
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2
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1
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3
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3
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1
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1
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3
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3
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1
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1
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668655
Kim
Brucella abortus nicotinamidas ...
Brucella abortus, Brucella abortus 544 / ATCC 23448
FEMS Microbiol. Lett.
234
289-295
2004
-
-
-
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1
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Nicotinamide clearance by Pnc1 ...
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Mycobacterium smegmatis has tw ...
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Reduced pyrazinamidase activit ...
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Boshoff
Purification, gene cloning, ta ...
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J. Bacteriol.
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246587
Raynaud
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Extracellular enzyme activitie ...
Mycobacterium kansasii, Mycobacterium tuberculosis, Mycobacterium tuberculosis variant bovis, Mycolicibacterium fortuitum, Mycolicibacterium phlei
Microbiology
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Frothingham
Identification, cloning, and e ...
Escherichia coli
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Zrez
Increased nicotinamideadenine ...
Plasmodium falciparum
Blood
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Purification and properties of ...
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Yan
Purification and characterizat ...
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Tissue distribution of the enz ...
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NAD metabolism in Vibrio chole ...
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246576
Wintzerith
Purification and characterizat ...
Mus musculus
Biochim. Biophys. Acta
613
191-202
1980
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246577
Fuller
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Determination of nicotinamide ...
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Methods Enzymol.
66
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1980
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246578
Tanigawa
Nicotinamide deamidase from Fl ...
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Methods Enzymol.
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1980
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246575
Foster
Pyridine nucleotide cycle of S ...
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1979
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246573
Gadd
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Kinetic studies of nicotinamid ...
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Int. J. Biochem.
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397-407
1974
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246574
Johnson
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Inhibition of nicotinamide dea ...
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Gillam
Nicotinamide deamidase from ra ...
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Arch. Biochem. Biophys.
157
268-284
1973
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246570
Albizati
Active-site studies on rabbit ...
Oryctolagus cuniculus
Biochemistry
11
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1972
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Tanigawa
Purification and properties of ...
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Pardee
Hyperproduction and purificati ...
Escherichia coli
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Petrack
Nicotinamide deaminase from ma ...
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246567
Sarma
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Studies on the enzymes involve ...
Aspergillus niger
Biochim. Biophys. Acta
81
311-322
1964
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