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Literature summary for 3.5.1.16 extracted from

  • Hlavacek, J.; Vitovcova, M.; Sazelova, P.; Picha, J.; Vanek, V.; Budesinsky, M.; Jiracek, J.; Gillner, D.M.; Holz, R.C.; Miksik, I.; Kasicka, V.
    Mono-N-acyl-2,6-diaminopimelic acid derivatives: analysis by electromigration and spectroscopic methods and examination of enzyme inhibitory activity (2014), Anal. Biochem., 467, 4-13.
    View publication on PubMed
Search for more literature for 3.5.1.16

Inhibitors

Inhibitors Comment Organism Structure
2-(acetylamino)-6-aminoheptanedioic acid
-
 Escherichia coli
2-amino-6-[(4-carboxy-3,3-dimethylbutanoyl)amino]heptanedioic acid slight inhibition Escherichia coli
2-amino-6-[(4-carboxy-3-methylbutanoyl)amino]heptanedioic acid slight inhibition Escherichia coli
2-amino-6-[(4-carboxybutanoyl)amino]heptanedioic acid
-
 Escherichia coli
2-amino-6-[[(2E)-4-methoxy-4-oxobut-2-enoyl]amino]heptanedioic acid slight inhibition Escherichia coli
additional information mono-N-acyl derivatives of 2,6-diaminopimelic acid as enzyme inhibitors, overview. No inhibition by 2-amino-6-[(2-methylpropanoyl)amino]heptanedioic acid, 2-amino-6-(butanoylamino)heptanedioic acid, 2-amino-6-[(2,2-dimethylpropanoyl)amino]heptanedioic acid, 2-amino-6-(pentanoylamino)heptanedioic acid, 2-amino-6-(benzoylamino)heptanedioic acid, 2-amino-6-[(4-carboxybutanoyl)amino]heptanedioic acid, 2-amino-6-[(4-carboxy-2,2,3,3-tetrafluorobutanoyl)amino]heptanedioic acid, 2-amino-6-[(3-ethoxy-3-oxopropanoyl)amino]heptanedioic acid, and 2-amino-6-[[(2R)-4-methoxy-2-methylpent-4-enoyl]amino]heptanedioic acid Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
N2-acetyl-L-ornithine + H2O Escherichia coli
-
 acetate + L-ornithine
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
 gene argE
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N2-acetyl-L-ornithine + H2O
-
 Escherichia coli acetate + L-ornithine
-
 ?

Synonyms

Synonyms Comment Organism
ArgE
-
 Escherichia coli

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
 assay at Escherichia coli

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Escherichia coli

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.48
-
 pH 7.5, 25°C Escherichia coli 2-(acetylamino)-6-aminoheptanedioic acid
1.28
-
 pH 7.5, 25°C Escherichia coli 2-amino-6-[[(2E)-4-methoxy-4-oxobut-2-enoyl]amino]heptanedioic acid
2.11
-
 pH 7.5, 25°C Escherichia coli 2-amino-6-[(4-carboxy-3,3-dimethylbutanoyl)amino]heptanedioic acid
2.63
-
 pH 7.5, 25°C Escherichia coli 2-amino-6-[(4-carboxybutanoyl)amino]heptanedioic acid