Cloned (Comment) | Organism |
---|---|
gene Aspa, expression analysis | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | Gata6flox/flox mice on a mixed 129S1/SvImJ and CD-1 background are bred with Lyz2-Cre+/- on a C57BL/6 background to yield Cre+/-Gata6-Mac mice and Cre-/- Gata6flox/flox littermate control mice. Nur7 mice bearing mutant Aspa alleles are on a C57BL/6J background and compared with C57BL/6J mice | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
N-acetylaspartate + H2O | Mus musculus | - |
acetate + L-aspartate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q8R3P0 | gene ASPA | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Mus musculus | - |
macrophage | resident peritoneal | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
N-acetylaspartate + H2O | - |
Mus musculus | acetate + L-aspartate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ASPA | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | mutations in gene Aspa lead to Canavan disease characterized by defective synthesis of myelin. Loss of expression of aspartoacylase does not lead to macrophage polarization | Mus musculus |
metabolism | enzyme substrate N-acetylaspartate is the second-most abundant metabolite in the brain, being produced by neurons and used by oligodendrocytes to coordinate their differentiation, energy production, and lipid synthesis | Mus musculus |
physiological function | Aspa might be relevant to the loss of viable macrophages in the peritoneum, transcription factor Gata6 regulates aspartoacylase expression in resident peritoneal macrophages and controls their survival, perturbed metabolic regulator aspartoacylase facilitates generation of acetyl CoA, gene expression profiling and phenotype, overview. Mutant mice lacking functional Aspa phenocopy the higher propensity to death leading to a contraction of resident peritoneal macrophages | Mus musculus |