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Literature summary for 3.5.1.15 extracted from

  • Gautier, E.; Ivanov, S.; Williams, J.; Huang, S.; Marcelin, G.; Fairfax, K.; Wang, P.; Francis, J.; Leone, P.; Wilson, D.; Artyomov, M.; Pearce, E.; Randolph, G.
    Gata6 regulates aspartoacylase expression in resident peritoneal macrophages and controls their survival (2014), J. Exp. Med., 211, 1525-1531.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
gene Aspa, expression analysis Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information Gata6flox/flox mice on a mixed 129S1/SvImJ and CD-1 background are bred with Lyz2-Cre+/- on a C57BL/6 background to yield Cre+/-Gata6-Mac mice and Cre-/- Gata6flox/flox littermate control mice. Nur7 mice bearing mutant Aspa alleles are on a C57BL/6J background and compared with C57BL/6J mice Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
N-acetylaspartate + H2O Mus musculus
-
acetate + L-aspartate
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus Q8R3P0 gene ASPA
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Mus musculus
-
macrophage resident peritoneal Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-acetylaspartate + H2O
-
Mus musculus acetate + L-aspartate
-
?

Synonyms

Synonyms Comment Organism
ASPA
-
Mus musculus

General Information

General Information Comment Organism
malfunction mutations in gene Aspa lead to Canavan disease characterized by defective synthesis of myelin. Loss of expression of aspartoacylase does not lead to macrophage polarization Mus musculus
metabolism enzyme substrate N-acetylaspartate is the second-most abundant metabolite in the brain, being produced by neurons and used by oligodendrocytes to coordinate their differentiation, energy production, and lipid synthesis Mus musculus
physiological function Aspa might be relevant to the loss of viable macrophages in the peritoneum, transcription factor Gata6 regulates aspartoacylase expression in resident peritoneal macrophages and controls their survival, perturbed metabolic regulator aspartoacylase facilitates generation of acetyl CoA, gene expression profiling and phenotype, overview. Mutant mice lacking functional Aspa phenocopy the higher propensity to death leading to a contraction of resident peritoneal macrophages Mus musculus