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Literature summary for 3.5.1.15 extracted from

  • Madhavarao, C.N.; Moffett, J.R.; Moore, R.A.; Viola, R.E.; Namboodiri, M.A.; Jacobowitz, D.M.
    Immunohistochemical localization of aspartoacylase in the rat central nervous system (2004), J. Comp. Neurol., 472, 318-329.
    View publication on PubMed
Search for more literature for 3.5.1.15

Localization

Localization Comment Organism GeneOntology No. Textmining
additional information immunohistochemical localization analysis Rattus norvegicus
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
N-acetylaspartic acid + H2O Rattus norvegicus enzyme mutations cause the Canavan disease L-asparatate + acetate
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 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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 male sprague-dawley rats
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Source Tissue

Source Tissue Comment Organism Textmining
brain
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 Rattus norvegicus
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central nervous system immunohistochemical localization analysis, high enzyme content in oligodendrocytes along with CC1, and in white matter, including the corpus callosum and the cerebellar white matter, less abundant enzyme content in grey matter, including cerebral cortex, descending neuronal fibers, and microglial cells, no enzyme in astroyctes and forebrain, overview Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-acetylaspartic acid + H2O
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 Rattus norvegicus L-asparatate + acetate
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 ?
N-acetylaspartic acid + H2O enzyme mutations cause the Canavan disease Rattus norvegicus L-asparatate + acetate
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 ?

Synonyms

Synonyms Comment Organism
ASPA
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 Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
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 assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
 assay at Rattus norvegicus