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Literature summary for 3.5.1.14 extracted from
- A cysteine-specific fluorescent switch for monitoring oxidative stress and quantification of aminoacylase-1 in blood serum (2016), Anal. Chem., 88, 12161-12168 .
Application
| Application | Comment | Organism |
|---|---|---|
| diagnostics | the enzyme is an important biomarker with potential prognostic utility in patients with delayed graft function following renal transplantation. The possibility of using 4-[(E)-2-[7-(diethylamino)-2-oxo-2H-1-benzopyran-3-yl]ethenyl]phenyl prop-2-enoate for quantification of aminoacylase-1 in blood serum samples is explored. Nontoxic nature and cell membrane permeability are key features of this probe and are ideally suited for imaging intracellular Cys in normal and cancerous cell lines .CA can be used for selective detection of Cys in the presence of the competing biothiols, cations, and anions of biological relevance. This reagent is successfully utilized for monitoring the hydrolysis of an important commercial drug molecule N-acetyl-L-cysteine by an industrially and biologically important endogenous enzyme, aminoacylase-1 | Homo sapiens |
| medicine | the enzyme is an important biomarker with potential prognostic utility in patients with delayed graft function following renal transplantation | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 4-[(E)-2-[7-(diethylamino)-2-oxo-2H-1-benzopyran-3-yl]ethenyl]phenyl prop-2-enoate | - |
Homo sapiens |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q03154 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| blood serum | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| N-acetyl-L-cysteine + H2O | - |
Homo sapiens | acetate + L-cysteine | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ACY-1 | - |
Homo sapiens |
| aminoacylase-1 | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7 | - |
assay at | Homo sapiens |
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Release 2023.1 (January 2023)
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