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Literature summary for 3.5.1.14 extracted from
- Application of aminoacylase I to the enantioselective resolution of alpha-amino acid esters and amides (2004), Tetrahedron, 15, 1933-1936.
No PubMed abstract available
Application
| Application | Comment | Organism |
|---|---|---|
| synthesis | biocatalytic production of optically active amino acids and their derivatives, which are broadly used as physiologically active compounds, chiral auxiliaries or synthons and as intermediates in pharmaceutical, food and agrochemistry | Aspergillus melleus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| N-acetyl-L-amino acid + H2O | Aspergillus melleus | - |
carboxylic acid + L-amino acid | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Aspergillus melleus | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | butanolysis and enantioselective hydrolysis of carboxylic acid esters, the activity of the enzyme is not restricted to N-acyl transfers, other substrates are e.g. L-aminobutyric acid alkyl esters, L-aminobutyric acid amide, L-4-hydroxyphenylglycine, and L-4-hydroxyphenylglycine amide, overview | Aspergillus melleus | ? | - |
? | |
| N-acetyl-L-amino acid + H2O | - |
Aspergillus melleus | carboxylic acid + L-amino acid | - |
? | |
| N-acetyl-L-amino acid + H2O | highly enantioselective hydrolysis of esters and amides, the L-configuration is preferred, overview | Aspergillus melleus | carboxylic acid + L-amino acid | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| aminoacylase I | - |
Aspergillus melleus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 25 | - |
assay at | Aspergillus melleus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
assay at | Aspergillus melleus |
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Release 2023.1 (January 2023)
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