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Literature summary for 3.5.1.13 extracted from
- Aryl acylamidase activity on acetylcholinesterase is high during early chicken brain development (2004), Protein J., 23, 325-333.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| BW284c51 | the specific AChE inhibitor inhibits the aryl amidase activity of acetylcholinesterase to a higher extent than the acetylcholinesterase activity | Gallus gallus |  |
| iso-ompa | i.e. tetra-isopropyl-pyrophosphoramide, specific inhibitor for BChE, inhibits also the aryl amidase activity | Gallus gallus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Gallus gallus | - |
white Leghorn chicken, acetylcholinesterase, EC 3.1.1.7, and butyrylcholinesterase, EC 3.1.1.8, are known to exhibit aryl acylamidase activities | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| native enzymes by immunoaffinity chromatography | Gallus gallus |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| an anilide + H2O = a carboxylate + aniline | mechanism of substrate specificity and reactivity change of the enzyme, acetylcholinesterase, EC 3.1.1.7, and butyrylcholinesterase, EC 3.1.1.8, are known to exhibit aryl acylamidase activities, overview | Gallus gallus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | enzyme activity on acetylcholinesterase is high during early chicken brain development, developmental profiles of aryl amidase activities along with acetylcholinesterase and butyrylcholinesterase activities from embryonic days E3 to hatching, E21, in Triton-X-100-solubilized homogenates from chicken embryonic brains, overview | Gallus gallus | - |
| embryo | - |
Gallus gallus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2-nitroacetanilide + H2O | - |
Gallus gallus | 2-nitroaniline + acetate | - |
? | |
| additional information | acetylcholinesterase, EC 3.1.1.7, and butyrylcholinesterase, EC 3.1.1.8, exhibit also aryl acylamidase activity | Gallus gallus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| aryl acylamidase | - |
Gallus gallus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Gallus gallus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7 | - |
assay at | Gallus gallus |
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Release 2023.1 (January 2023)
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