Literature summary for 3.5.1.13 extracted from

Hsu, L.L.; Halaris, A.E.; Freedman, D.X.
Rat brain aryl acylamidase: further characterization of multiple forms (1982), Int. J. Biochem., 14, 581-584.

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Activating Compound

Activating Compound	Comment	Organism	Structure
6-methoxy-harmalan	enhances activity of enzyme form AAA-1 and AAA-2	Rattus norvegicus
6-methoxy-harman	enhances activity of enzyme form AAA-1 and AAA-2	Rattus norvegicus
chlorimipramine	stimulates enzyme form AAA-2	Rattus norvegicus
cyproheptadine	stimulates enzyme form AAA-2	Rattus norvegicus
Harmaline	enhances activity of enzyme form AAA-1 and AAA-2	Rattus norvegicus
harmalol	enhances activity of enzyme form of AAA-2	Rattus norvegicus
methiothepin	stimulates enzyme form AAA-2	Rattus norvegicus

Inhibitors

Inhibitors	Comment	Organism	Structure
1,2,3,4-tetrahydro-beta-carboline	competitive inhibition of AAA-1, slight inhibition of enzyme form AAA-2	Rattus norvegicus
6-hydroxy-tetrahydroharman	slight inhibition of enzyme form AAA-1 and AAA-2	Rattus norvegicus
chlorimipramine	enzyme form AAA-1	Rattus norvegicus
cyproheptadine	enzyme form AAA-1	Rattus norvegicus
harmalol	enzyme form of AAA-1	Rattus norvegicus
harminic acid	slight inhibition of enzyme form AAA-1 and AAA-2	Rattus norvegicus
methiothepin	enzyme form AAA-1	Rattus norvegicus
neostigmine	inhibition of enzyme form AAA-2, no effect of enzyme form AAA-1	Rattus norvegicus
tetrahydroharman	-	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	enzyme form AAA-1 and AAA-2	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	-	Rattus norvegicus	-

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Release 2023.1 (January 2023)