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Literature summary for 3.5.1.124 extracted from
- The deglycase activity of DJ-1 mitigates alpha-synuclein glycation and aggregation in dopaminergic cells Role of oxidative stress mediated downregulation of DJ-1 in Parkinsons disease (2019), Free Radic. Biol. Med., 135, 28-37 .
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| DJ-1 gene is subcloned from pLenti6-DJ-1-V5-WT plasmid into the pRetroX-Tight-Puro Advanced vector. The confirmed clone is transfected into HEK-293 cells | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q99497 | cf. EC 4.2.1.130 | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| N6-(1-hydroxy-2-oxopropyl)-[alpha-synuclein]-L-lysine + H2O | - |
Homo sapiens | [alpha-synuclein]-L-lysine + lactate | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| DJ-1 | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 30 | - |
assay at | Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | reduced DJ-1 activity due to mutations or oxidative stress may lead to the accumulation of glycated alpha-synuclein and its aggregates | Homo sapiens |
| physiological function | the deglycase activity of DJ-1 mitigates alpha-synuclein glycation and aggregation in dopaminergic cells | Homo sapiens |
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Release 2023.1 (January 2023)
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