Literature summary for 3.5.1.124 extracted from

Mihoub, M.; Abdallah, J.; Richarme, G.
Protein repair from glycation by glyoxals by the DJ-1 family Maillard deglycases (2017), Adv. Exp. Med. Biol., 1037, 133-147 .

Search for more literature for 3.5.1.124

Application

Application	Comment	Organism
diagnostics	secreted DJ-1 levels in serum and DJ-1-binding compounds will be a diagnostic biomarker and therapeutic drug for neurodegenerative diseases	Homo sapiens
drug development	secreted DJ-1 levels in serum and DJ-1-binding compounds will be a diagnostic biomarker and therapeutic drug for neurodegenerative diseases	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q99497	-	-

Synonyms

Synonyms	Comment	Organism
DJ-1 deglycase	-	Homo sapiens
Maillard deglycase	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	by degrading Maillard adducts formed between carbonyls and thiols or amino groups, the DJ-1 family Maillard deglycases prevent the formation of the advanced glycation end products (AGEs) that arise from Maillard adducts after dehydrations, oxidations and rearrangements. Since glycation is involved in ageing, cancer, atherosclerosis and cataracts, as well as post-diabetic, neurovegetatives and renal and autoimmune diseases, the DJ-1 deglycases are likely to play an important role in preventing these diseases. These deglycases, especially those from thermophilic organisms, may also be used to prevent the formation of dietary AGEs during food processing, sterilization and storage. They prevent acrylamide formation in food, likely by degrading the asparagine/glyoxal Maillard adducts responsible for its formation. Since Maillard adducts are the substrates of the DJ-1 family deglycases	Homo sapiens

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Release 2023.1 (January 2023)