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Literature summary for 3.5.1.12 extracted from

  • Hart, P.S.; Hymes, J.; Wolf, B.
    Isoforms of human serum biotinidase (1991), Clin. Chim. Acta, 197, 257-264.
    View publication on PubMed

Application

Application Comment Organism
medicine plasma biotinidase activity assay for diagnosis and screen newborn infants for biotinidase deficiency, treatment of inborn metabolism errors with large doses of biotin Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
60000
-
gel filtration, treated with N-glycanase Homo sapiens
71000
-
gel filtration, treated with neuraminidase Homo sapiens
76500
-
gel filtration, SDS-PAGE, normal serum biotinidase has 9 isoforms Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
biotin amide + H2O Homo sapiens cleaves D-biotinylamides and esters, recycling of the vitamin ?
-
?
epsilon-N-biotinyl-L-lysine + H2O Homo sapiens
-
?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
human
-

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
blood serum, plasma, leukocytes Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
biotin amide + H2O cleaves D-biotinylamides and esters, recycling of the vitamin Homo sapiens ?
-
?
epsilon-N-biotinyl-L-lysine + H2O
-
Homo sapiens biotin + L-lysine
-
ir
epsilon-N-biotinyl-L-lysine + H2O
-
Homo sapiens ?
-
?