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Literature summary for 3.5.1.119 extracted from

  • Yoo, J.; Kahne, S.; Darwin, K.
    A conserved loop sequence of the proteasome system depupylase Dop regulates substrate selectivity in Mycobacterium tuberculosis (2022), J. Biol. Chem., 298, 102478.
    View publication on PubMed
Search for more literature for 3.5.1.119

Protein Variants

Protein Variants Comment Organism
additional information complementation of a Dop deletion strain with a variant deleted for the coding sequence for the 24 most conserved amino acids leads to a reduced pupylome. Smaller amino acid deletions in the Dop loop also results in decreased pupylome abundance. Deletions nearer to the amino terminus have greater decreases in pupylome levels. A strain producing Dop lacking the amino acids tryptophan, aspartate, tyrosine, glutamate, and valine has the most similar pupylome to the variant deleted for the coding sequence for the 24 most conserved amino acids Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
[prokaryotic ubiquitin-like protein]-gamma-L-glutamyl-[Bcp protein]-L-lysine + H2O Mycobacterium tuberculosis
-
 [prokaryotic ubiquitin-like protein]-L-glutamate + [Bcp protein]-L-lysine
-
 ?
[prokaryotic ubiquitin-like protein]-gamma-L-glutamyl-[FabD protein]-L-lysine + H2O Mycobacterium tuberculosis
-
 [prokaryotic ubiquitin-like protein]-L-glutamate + [FabD protein]-L-lysine
-
 ?
[prokaryotic ubiquitin-like protein]-gamma-L-glutamyl-[FabD protein]-L-lysine + H2O Mycobacterium tuberculosis H37Rv
-
 [prokaryotic ubiquitin-like protein]-L-glutamate + [FabD protein]-L-lysine
-
 ?
[prokaryotic ubiquitin-like protein]-gamma-L-glutamyl-[FadA protein]-L-lysine + H2O Mycobacterium tuberculosis
-
 [prokaryotic ubiquitin-like protein]-L-glutamate + [FadA protein]-L-lysine
-
 ?
[prokaryotic ubiquitin-like protein]-gamma-L-glutamyl-[FusA protein]-L-lysine + H2O Mycobacterium tuberculosis
-
 [prokaryotic ubiquitin-like protein]-L-glutamate + [FusA protein]-L-lysine
-
 ?
[prokaryotic ubiquitin-like protein]-gamma-L-glutamyl-[GlmU protein]-L-lysine + H2O Mycobacterium tuberculosis
-
 [prokaryotic ubiquitin-like protein]-L-glutamate + [GlmU protein]-L-lysine
-
 ?
[prokaryotic ubiquitin-like protein]-gamma-L-glutamyl-[Icl protein]-L-lysine + H2O Mycobacterium tuberculosis
-
 [prokaryotic ubiquitin-like protein]-L-glutamate + [Icl protein]-L-lysine
-
 ?
[prokaryotic ubiquitin-like protein]-gamma-L-glutamyl-[Icl protein]-L-lysine + H2O Mycobacterium tuberculosis H37Rv
-
 [prokaryotic ubiquitin-like protein]-L-glutamate + [Icl protein]-L-lysine
-
 ?
[prokaryotic ubiquitin-like protein]-gamma-L-glutamyl-[Ino1 protein]-L-lysine + H2O Mycobacterium tuberculosis
-
 [prokaryotic ubiquitin-like protein]-L-glutamate + [Ino1 protein]-L-lysine
-
 ?
[prokaryotic ubiquitin-like protein]-gamma-L-glutamyl-[KasA protein]-L-lysine + H2O Mycobacterium tuberculosis
-
 [prokaryotic ubiquitin-like protein]-L-glutamate + [KasA protein]-L-lysine
-
 ?
[prokaryotic ubiquitin-like protein]-gamma-L-glutamyl-[KasA protein]-L-lysine + H2O Mycobacterium tuberculosis H37Rv
-
 [prokaryotic ubiquitin-like protein]-L-glutamate + [KasA protein]-L-lysine
-
 ?
[prokaryotic ubiquitin-like protein]-gamma-L-glutamyl-[LeuD protein]-L-lysine + H2O Mycobacterium tuberculosis
-
 [prokaryotic ubiquitin-like protein]-L-glutamate + [LeuD protein]-L-lysine
-
 ?
[prokaryotic ubiquitin-like protein]-gamma-L-glutamyl-[Log protein]-L-lysine + H2O Mycobacterium tuberculosis
-
 [prokaryotic ubiquitin-like protein]-L-glutamate + [Log protein]-L-lysine
-
 ?
[prokaryotic ubiquitin-like protein]-gamma-L-glutamyl-[Log protein]-L-lysine + H2O Mycobacterium tuberculosis H37Rv
-
 [prokaryotic ubiquitin-like protein]-L-glutamate + [Log protein]-L-lysine
-
 ?
[prokaryotic ubiquitin-like protein]-gamma-L-glutamyl-[Mpa protein]-L-lysine + H2O Mycobacterium tuberculosis
-
 [prokaryotic ubiquitin-like protein]-L-glutamate + [Mpa protein]-L-lysine
-
 ?
[prokaryotic ubiquitin-like protein]-gamma-L-glutamyl-[Mtra protein]-L-lysine + H2O Mycobacterium tuberculosis
-
 [prokaryotic ubiquitin-like protein]-L-glutamate + [MtrA protein]-L-lysine
-
 ?
[prokaryotic ubiquitin-like protein]-gamma-L-glutamyl-[MurA protein]-L-lysine + H2O Mycobacterium tuberculosis
-
 [prokaryotic ubiquitin-like protein]-L-glutamate + [MurA protein]-L-lysine
-
 ?
[prokaryotic ubiquitin-like protein]-gamma-L-glutamyl-[NuoE protein]-L-lysine + H2O Mycobacterium tuberculosis
-
 [prokaryotic ubiquitin-like protein]-L-glutamate + [NuoE protein]-L-lysine
-
 ?
[prokaryotic ubiquitin-like protein]-gamma-L-glutamyl-[PafA protein]-L-lysine + H2O Mycobacterium tuberculosis
-
 [prokaryotic ubiquitin-like protein]-L-glutamate + [PafA protein]-L-lysine
-
 ?
[prokaryotic ubiquitin-like protein]-gamma-L-glutamyl-[PanB protein]-L-lysine + H2O Mycobacterium tuberculosis
-
 [prokaryotic ubiquitin-like protein]-L-glutamate + [PanB protein]-L-lysine
-
 ?
[prokaryotic ubiquitin-like protein]-gamma-L-glutamyl-[PanB protein]-L-lysine + H2O Mycobacterium tuberculosis H37Rv
-
 [prokaryotic ubiquitin-like protein]-L-glutamate + [PanB protein]-L-lysine
-
 ?
[prokaryotic ubiquitin-like protein]-gamma-L-glutamyl-[PhoH2 protein]-L-lysine + H2O Mycobacterium tuberculosis
-
 [prokaryotic ubiquitin-like protein]-L-glutamate + [PhoH2 protein]-L-lysine
-
 ?
[prokaryotic ubiquitin-like protein]-gamma-L-glutamyl-[RecA protein]-L-lysine + H2O Mycobacterium tuberculosis
-
 [prokaryotic ubiquitin-like protein]-L-glutamate + [RecA protein]-L-lysine
-
 ?
[prokaryotic ubiquitin-like protein]-gamma-L-glutamyl-[Rv0073 protein]-L-lysine + H2O Mycobacterium tuberculosis
-
 [prokaryotic ubiquitin-like protein]-L-glutamate + [Rv0073 protein]-L-lysine
-
 ?
[prokaryotic ubiquitin-like protein]-gamma-L-glutamyl-[Rv2859c protein]-L-lysine + H2O Mycobacterium tuberculosis
-
 [prokaryotic ubiquitin-like protein]-L-glutamate + [Rv2859c protein]-L-lysine
-
 ?
[prokaryotic ubiquitin-like protein]-gamma-L-glutamyl-[SahH protein]-L-lysine + H2O Mycobacterium tuberculosis
-
 [prokaryotic ubiquitin-like protein]-L-glutamate + [SahH protein]-L-lysine
-
 ?

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis P9WNU9
-
-
Mycobacterium tuberculosis H37Rv P9WNU9
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
[prokaryotic ubiquitin-like protein]-gamma-L-glutamyl-[Bcp protein]-L-lysine + H2O
-
 Mycobacterium tuberculosis [prokaryotic ubiquitin-like protein]-L-glutamate + [Bcp protein]-L-lysine
-
 ?
[prokaryotic ubiquitin-like protein]-gamma-L-glutamyl-[FabD protein]-L-lysine + H2O
-
 Mycobacterium tuberculosis [prokaryotic ubiquitin-like protein]-L-glutamate + [FabD protein]-L-lysine
-
 ?
[prokaryotic ubiquitin-like protein]-gamma-L-glutamyl-[FabD protein]-L-lysine + H2O
-
 Mycobacterium tuberculosis H37Rv [prokaryotic ubiquitin-like protein]-L-glutamate + [FabD protein]-L-lysine
-
 ?
[prokaryotic ubiquitin-like protein]-gamma-L-glutamyl-[FadA protein]-L-lysine + H2O
-
 Mycobacterium tuberculosis [prokaryotic ubiquitin-like protein]-L-glutamate + [FadA protein]-L-lysine
-
 ?
[prokaryotic ubiquitin-like protein]-gamma-L-glutamyl-[FusA protein]-L-lysine + H2O
-
 Mycobacterium tuberculosis [prokaryotic ubiquitin-like protein]-L-glutamate + [FusA protein]-L-lysine
-
 ?
[prokaryotic ubiquitin-like protein]-gamma-L-glutamyl-[GlmU protein]-L-lysine + H2O
-
 Mycobacterium tuberculosis [prokaryotic ubiquitin-like protein]-L-glutamate + [GlmU protein]-L-lysine
-
 ?
[prokaryotic ubiquitin-like protein]-gamma-L-glutamyl-[Icl protein]-L-lysine + H2O
-
 Mycobacterium tuberculosis [prokaryotic ubiquitin-like protein]-L-glutamate + [Icl protein]-L-lysine
-
 ?
[prokaryotic ubiquitin-like protein]-gamma-L-glutamyl-[Icl protein]-L-lysine + H2O
-
 Mycobacterium tuberculosis H37Rv [prokaryotic ubiquitin-like protein]-L-glutamate + [Icl protein]-L-lysine
-
 ?
[prokaryotic ubiquitin-like protein]-gamma-L-glutamyl-[Ino1 protein]-L-lysine + H2O
-
 Mycobacterium tuberculosis [prokaryotic ubiquitin-like protein]-L-glutamate + [Ino1 protein]-L-lysine
-
 ?
[prokaryotic ubiquitin-like protein]-gamma-L-glutamyl-[KasA protein]-L-lysine + H2O
-
 Mycobacterium tuberculosis [prokaryotic ubiquitin-like protein]-L-glutamate + [KasA protein]-L-lysine
-
 ?
[prokaryotic ubiquitin-like protein]-gamma-L-glutamyl-[KasA protein]-L-lysine + H2O
-
 Mycobacterium tuberculosis H37Rv [prokaryotic ubiquitin-like protein]-L-glutamate + [KasA protein]-L-lysine
-
 ?
[prokaryotic ubiquitin-like protein]-gamma-L-glutamyl-[LeuD protein]-L-lysine + H2O
-
 Mycobacterium tuberculosis [prokaryotic ubiquitin-like protein]-L-glutamate + [LeuD protein]-L-lysine
-
 ?
[prokaryotic ubiquitin-like protein]-gamma-L-glutamyl-[Log protein]-L-lysine + H2O
-
 Mycobacterium tuberculosis [prokaryotic ubiquitin-like protein]-L-glutamate + [Log protein]-L-lysine
-
 ?
[prokaryotic ubiquitin-like protein]-gamma-L-glutamyl-[Log protein]-L-lysine + H2O
-
 Mycobacterium tuberculosis H37Rv [prokaryotic ubiquitin-like protein]-L-glutamate + [Log protein]-L-lysine
-
 ?
[prokaryotic ubiquitin-like protein]-gamma-L-glutamyl-[Mpa protein]-L-lysine + H2O
-
 Mycobacterium tuberculosis [prokaryotic ubiquitin-like protein]-L-glutamate + [Mpa protein]-L-lysine
-
 ?
[prokaryotic ubiquitin-like protein]-gamma-L-glutamyl-[Mtra protein]-L-lysine + H2O
-
 Mycobacterium tuberculosis [prokaryotic ubiquitin-like protein]-L-glutamate + [MtrA protein]-L-lysine
-
 ?
[prokaryotic ubiquitin-like protein]-gamma-L-glutamyl-[MurA protein]-L-lysine + H2O
-
 Mycobacterium tuberculosis [prokaryotic ubiquitin-like protein]-L-glutamate + [MurA protein]-L-lysine
-
 ?
[prokaryotic ubiquitin-like protein]-gamma-L-glutamyl-[NuoE protein]-L-lysine + H2O
-
 Mycobacterium tuberculosis [prokaryotic ubiquitin-like protein]-L-glutamate + [NuoE protein]-L-lysine
-
 ?
[prokaryotic ubiquitin-like protein]-gamma-L-glutamyl-[PafA protein]-L-lysine + H2O
-
 Mycobacterium tuberculosis [prokaryotic ubiquitin-like protein]-L-glutamate + [PafA protein]-L-lysine
-
 ?
[prokaryotic ubiquitin-like protein]-gamma-L-glutamyl-[PanB protein]-L-lysine + H2O
-
 Mycobacterium tuberculosis [prokaryotic ubiquitin-like protein]-L-glutamate + [PanB protein]-L-lysine
-
 ?
[prokaryotic ubiquitin-like protein]-gamma-L-glutamyl-[PanB protein]-L-lysine + H2O
-
 Mycobacterium tuberculosis H37Rv [prokaryotic ubiquitin-like protein]-L-glutamate + [PanB protein]-L-lysine
-
 ?
[prokaryotic ubiquitin-like protein]-gamma-L-glutamyl-[PhoH2 protein]-L-lysine + H2O
-
 Mycobacterium tuberculosis [prokaryotic ubiquitin-like protein]-L-glutamate + [PhoH2 protein]-L-lysine
-
 ?
[prokaryotic ubiquitin-like protein]-gamma-L-glutamyl-[RecA protein]-L-lysine + H2O
-
 Mycobacterium tuberculosis [prokaryotic ubiquitin-like protein]-L-glutamate + [RecA protein]-L-lysine
-
 ?
[prokaryotic ubiquitin-like protein]-gamma-L-glutamyl-[Rv0073 protein]-L-lysine + H2O
-
 Mycobacterium tuberculosis [prokaryotic ubiquitin-like protein]-L-glutamate + [Rv0073 protein]-L-lysine
-
 ?
[prokaryotic ubiquitin-like protein]-gamma-L-glutamyl-[Rv2859c protein]-L-lysine + H2O
-
 Mycobacterium tuberculosis [prokaryotic ubiquitin-like protein]-L-glutamate + [Rv2859c protein]-L-lysine
-
 ?
[prokaryotic ubiquitin-like protein]-gamma-L-glutamyl-[SahH protein]-L-lysine + H2O
-
 Mycobacterium tuberculosis [prokaryotic ubiquitin-like protein]-L-glutamate + [SahH protein]-L-lysine
-
 ?

Synonyms

Synonyms Comment Organism
depupylase
-
 Mycobacterium tuberculosis
Dop
-
 Mycobacterium tuberculosis