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Literature summary for 3.5.1.11 extracted from
- Rhodotorula aurantiaca penicillin V acylase: active site characterization and fluorometric studies (2009), J. Photochem. Photobiol. B, 97, 109-116.
Application
| Application | Comment | Organism |
|---|---|---|
| synthesis | PVA is a pharmaceutically important enzyme to produce 6-aminopenicillanic acid | Buckleyzyma aurantiaca |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| N-bromosuccinimide | - |
Buckleyzyma aurantiaca |  |
| Phenylmethylsulfonylfluoride | - |
Buckleyzyma aurantiaca | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| penicillin V + H2O | Buckleyzyma aurantiaca | - |
phenoxyacetate + 6-aminopenicillinate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Buckleyzyma aurantiaca | - |
NCIM 3425 | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| penicillin V + H2O | - |
Buckleyzyma aurantiaca | phenoxyacetate + 6-aminopenicillinate | - |
? | |
| penicillin V + H2O | involvement of serine and tryptophan in the enzyme activity | Buckleyzyma aurantiaca | phenoxyacetate + 6-aminopenicillinate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| More | penicillin acylases share a common structural fold and possess a catalytic serine or cysteine or threonine residue at the N-terminal end | Buckleyzyma aurantiaca |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| More | PVA is a member of the N-terminal nucleophile, Ntn, hydrolase superfamily | Buckleyzyma aurantiaca |
| penicillin V acylase | - |
Buckleyzyma aurantiaca |
| PVA | - |
Buckleyzyma aurantiaca |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | inhibition kinetics, effects of tryptophan and serine modifications by phenylmethylsulfonylfluoride and N-bromosuccinimide, fluorometric studies, overview | Buckleyzyma aurantiaca |
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Release 2023.1 (January 2023)
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