Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
patients with atopic dermatitis | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
epidermis | in extracts of whole epidermis biopsies from patients with atopic dermatitis, sphingomyelin deacylase activities are significantly (3-fold) increased over healthy controls in the particulate fraction, whereas there is no significant difference in the activity of sphingomyelinase between atopic dermatitis and healthy control | Homo sapiens | - |
lymphocyte | in peripheral blood lymphocytes of patients with atopic dermatitis, there is no increase in activity compared with healthy controls | Homo sapiens | - |
stratum corneum | from lesional forearm skin (volar side) of patients with atopic dermatitis, sphingomyelin deacylase activity is at least 5times higher than in the stratum corneum of healthy controls. In stratum corneum from nonlesional skin of patients with atopic dermatitis, SM deacylase activity is at least three times higher than in healthy controls. Stratum corneum from contact dermatitis patients shows levels of sphingomyelin deacylase similar to healthy controls | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
16-(9-anthroyloxy)hexadecanoyl-sphingosylphosphorylcholine + H2O | - |
Homo sapiens | 16-(9-anthroyloxy)hexadecanoic acid + sphingosylphosphorylcholine | - |
? | |
N-palmitoyl-sphingosylphosphorylcholine + H2O | - |
Homo sapiens | palmitic acid + sphingosylphosphorylcholine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
SM deacylase | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
4.7 | - |
assay at | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | high-expression of sphingomyelin deacylase is an important determinant of ceramide deficiency leading to barrier disruption in atopic dermatitis. The enzyme is highly expressed in the epidermis of patients with atopic dermatitis, and competes with sphingomyelinase or beta-glucocerebrosidase for the common substrate sphingomyelin or glucosylceramide, which leads to the ceramide deficiency of the stratum corneum in atopic dermatitis | Homo sapiens |