Literature summary for 3.5.1.108 extracted from

Emiola, A.; Andrews, S.; Heller, C.; George, J.
Crosstalk between the lipopolysaccharide and phospholipid pathways during outer membrane biogenesis in Escherichia coli (2016), Proc. Natl. Acad. Sci. USA, 113, 3108-3113 .

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General Stability

General Stability	Organism
palmitoyl-CoA induces a strong inhibitory effect on FabI. Due to the inhibition of FabI, LpxC would be stabilized	Escherichia coli

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	P0A725	W3110	-
Escherichia coli K12	P0A725	W3110	-

Synonyms

Synonyms	Comment	Organism
LpxC	-	Escherichia coli

General Information

General Information	Comment	Organism
metabolism	a model for the biosynthesis of the outer membrane in Escherichia coli is presented. Lipopolysaccharide is an endotoxin that elicits a strong immune response from humans, and its biosynthesis is in part regulated via degradation of LpxC and WaaA enzymes by the protease FtsH. Addition of palmitic acid to the growth medium of wild-type Escherichia coli elevates the levels of LpxC by 1.7fold. Palmitoyl-CoA induces a strong inhibitory effect on FabI. Due to the inhibition of FabI, LpxC would be stabilized. Thus, elevated cellular palmitoyl-CoA concentrations has an opposite effect on LpxC stability than the free-form of palmitic acid	Escherichia coli

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Release 2023.1 (January 2023)