Literature summary for 3.5.1.108 extracted from

Piizzi, G.; Parker, D.T.; Peng, Y.; Dobler, M.; Patnaik, A.; Wattanasin, S.; Liu, E.; Lenoir, F.; Nunez, J.; Kerrigan, J.; McKenney, D.; Osborne, C.; Yu, D.; Lanieri, L.; Bojkovic, J.; Dzink-Fox, J.; Lilly, M.D.; Sprague, E.R.; Lu, Y.; Wang, H.; Ranjitkar, S.; Xie, L.; Wang, B.; Glick, M.; Hamann, L.G.
Design, synthesis, and properties of a potent inhibitor of Pseudomonas aeruginosa deacetylase LpxC (2017), J. Med. Chem., 60, 5002-5014 .

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
UDP-3-O-[(3R)-3-hydroxymyristoyl]-N-acetyl-alpha-D-glucosamine + H2O	Pseudomonas aeruginosa	first committed step in the biosynthesis of lipid A	UDP-3-O-[(3R)-3-hydroxymyristoyl]-alpha-D-glucosamine + acetate	-	?

Organism

Organism	UniProt	Comment	Textmining
Pseudomonas aeruginosa	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
UDP-3-O-[(3R)-3-hydroxymyristoyl]-N-acetyl-alpha-D-glucosamine + H2O	-	Pseudomonas aeruginosa	UDP-3-O-[(3R)-3-hydroxymyristoyl]-alpha-D-glucosamine + acetate	-	?
UDP-3-O-[(3R)-3-hydroxymyristoyl]-N-acetyl-alpha-D-glucosamine + H2O	first committed step in the biosynthesis of lipid A	Pseudomonas aeruginosa	UDP-3-O-[(3R)-3-hydroxymyristoyl]-alpha-D-glucosamine + acetate	-	?

Synonyms

Synonyms	Comment	Organism
LpxC	-	Pseudomonas aeruginosa

General Information

General Information	Comment	Organism
metabolism	first committed step in the biosynthesis of lipid A	Pseudomonas aeruginosa

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Release 2023.1 (January 2023)