Crystallization (Comment) | Organism |
---|---|
Aquifex aeolicus LpxC with bound UDP-3-O-(acyl)-glucosamine and with 2 and 9, X-ray diffraction structure determination and analysis. Cocrystal structure of Aquifex aeolicus LpxC with bound product UDP-3-O-(acyl)-glucosamine and Pseudomonas aeruginosa with bound 27b docking model, overview | Aquifex aeolicus |
X-ray diffraction structure determination and analysis | Pseudomonas aeruginosa |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-({4-[(2R,6S)-2,6-dimethylmorpholin-4-yl]phenoxy}methyl)-N-hydroxyoxane-4-carboxamide | - |
Aquifex aeolicus | |
4-({4-[(2R,6S)-2,6-dimethylmorpholin-4-yl]phenoxy}methyl)-N-hydroxyoxane-4-carboxamide | - |
Escherichia coli | |
4-({4-[(2R,6S)-2,6-dimethylmorpholin-4-yl]phenoxy}methyl)-N-hydroxyoxane-4-carboxamide | - |
Pseudomonas aeruginosa | |
4-({4-[(4-{[(2R,6S)-2,6-dimethylmorpholin-4-yl]methyl}phenyl)ethynyl]phenoxy}methyl)-N-hydroxyoxane-4-carboxamide | - |
Aquifex aeolicus | |
4-({4-[(4-{[(2R,6S)-2,6-dimethylmorpholin-4-yl]methyl}phenyl)ethynyl]phenoxy}methyl)-N-hydroxyoxane-4-carboxamide | - |
Escherichia coli | |
4-({4-[(4-{[(2R,6S)-2,6-dimethylmorpholin-4-yl]methyl}phenyl)ethynyl]phenoxy}methyl)-N-hydroxyoxane-4-carboxamide | - |
Pseudomonas aeruginosa | |
4-({[4-(4-chlorophenoxy)phenyl]sulfanyl}methyl)-N-hydroxyoxane-4-carboxamide | - |
Aquifex aeolicus | |
4-({[4-(4-chlorophenoxy)phenyl]sulfanyl}methyl)-N-hydroxyoxane-4-carboxamide | - |
Escherichia coli | |
4-({[4-(4-chlorophenoxy)phenyl]sulfanyl}methyl)-N-hydroxyoxane-4-carboxamide | - |
Pseudomonas aeruginosa | |
4-[(4-{2-[(dimethylamino)methyl]morpholin-4-yl}phenoxy)methyl]-N-hydroxyoxane-4-carboxamide | - |
Aquifex aeolicus | |
4-[(4-{2-[(dimethylamino)methyl]morpholin-4-yl}phenoxy)methyl]-N-hydroxyoxane-4-carboxamide | - |
Escherichia coli | |
4-[(4-{2-[(dimethylamino)methyl]morpholin-4-yl}phenoxy)methyl]-N-hydroxyoxane-4-carboxamide | - |
Pseudomonas aeruginosa | |
4-[(4-{[4-({2-[(dimethylamino)methyl]morpholin-4-yl}methyl)phenyl]ethynyl}phenoxy)methyl]-N-hydroxyoxane-4-carboxamide | - |
Aquifex aeolicus | |
4-[(4-{[4-({2-[(dimethylamino)methyl]morpholin-4-yl}methyl)phenyl]ethynyl}phenoxy)methyl]-N-hydroxyoxane-4-carboxamide | - |
Escherichia coli | |
4-[(4-{[4-({2-[(dimethylamino)methyl]morpholin-4-yl}methyl)phenyl]ethynyl}phenoxy)methyl]-N-hydroxyoxane-4-carboxamide | - |
Pseudomonas aeruginosa | |
4-{[4-(4-acetylpiperazin-1-yl)phenoxy]methyl}-N-hydroxyoxane-4-carboxamide | - |
Aquifex aeolicus | |
4-{[4-(4-acetylpiperazin-1-yl)phenoxy]methyl}-N-hydroxyoxane-4-carboxamide | - |
Escherichia coli | |
4-{[4-(4-acetylpiperazin-1-yl)phenoxy]methyl}-N-hydroxyoxane-4-carboxamide | - |
Pseudomonas aeruginosa | |
4-{[4-({4-[(4-acetylpiperazin-1-yl)methyl]phenyl}ethynyl)phenoxy]methyl}-N-hydroxyoxane-4-carboxamide | - |
Aquifex aeolicus | |
4-{[4-({4-[(4-acetylpiperazin-1-yl)methyl]phenyl}ethynyl)phenoxy]methyl}-N-hydroxyoxane-4-carboxamide | - |
Escherichia coli | |
4-{[4-({4-[(4-acetylpiperazin-1-yl)methyl]phenyl}ethynyl)phenoxy]methyl}-N-hydroxyoxane-4-carboxamide | - |
Pseudomonas aeruginosa | |
additional information | synthesis, structure, structure-activity relationship, and inhibitory potencies of tetrahydropyran-based LpxC inhibitors, overview | Aquifex aeolicus | |
additional information | synthesis, structure, structure-activity relationship, and inhibitory potencies of tetrahydropyran-based LpxC inhibitors, overview | Escherichia coli | |
additional information | synthesis, structure, structure-activity relationship, and inhibitory potencies of tetrahydropyran-based LpxC inhibitors, overview | Pseudomonas aeruginosa | |
N,4-dihydroxy-1-{[4-({4-[(morpholin-4-yl)methyl]phenyl}ethynyl)phenoxy]methyl}cyclohexane-1-carboxamide | - |
Aquifex aeolicus | |
N,4-dihydroxy-1-{[4-({4-[(morpholin-4-yl)methyl]phenyl}ethynyl)phenoxy]methyl}cyclohexane-1-carboxamide | - |
Escherichia coli | |
N,4-dihydroxy-1-{[4-({4-[(morpholin-4-yl)methyl]phenyl}ethynyl)phenoxy]methyl}cyclohexane-1-carboxamide | - |
Pseudomonas aeruginosa | |
N-hydroxy-4-({4-[(4-{[4-(propan-2-yl)piperazin-1-yl]methyl}phenyl)ethynyl]phenoxy}methyl)oxane-4-carboxamide | - |
Aquifex aeolicus | |
N-hydroxy-4-({4-[(4-{[4-(propan-2-yl)piperazin-1-yl]methyl}phenyl)ethynyl]phenoxy}methyl)oxane-4-carboxamide | - |
Escherichia coli | |
N-hydroxy-4-({4-[(4-{[4-(propan-2-yl)piperazin-1-yl]methyl}phenyl)ethynyl]phenoxy}methyl)oxane-4-carboxamide | - |
Pseudomonas aeruginosa | |
N-hydroxy-4-({4-[4-(propan-2-yl)piperazin-1-yl]phenoxy}methyl)oxane-4-carboxamide | - |
Aquifex aeolicus | |
N-hydroxy-4-({4-[4-(propan-2-yl)piperazin-1-yl]phenoxy}methyl)oxane-4-carboxamide | - |
Escherichia coli | |
N-hydroxy-4-({4-[4-(propan-2-yl)piperazin-1-yl]phenoxy}methyl)oxane-4-carboxamide | - |
Pseudomonas aeruginosa | |
N-hydroxy-4-({[4-({4-[(morpholin-4-yl)methyl]phenyl}ethynyl)phenyl]sulfanyl}methyl)oxane-4-carboxamide | - |
Aquifex aeolicus | |
N-hydroxy-4-({[4-({4-[(morpholin-4-yl)methyl]phenyl}ethynyl)phenyl]sulfanyl}methyl)oxane-4-carboxamide | - |
Escherichia coli | |
N-hydroxy-4-({[4-({4-[(morpholin-4-yl)methyl]phenyl}ethynyl)phenyl]sulfanyl}methyl)oxane-4-carboxamide | - |
Pseudomonas aeruginosa | |
N-hydroxy-4-methoxy-1-{[4-({4-[(morpholin-4-yl)methyl]phenyl}ethynyl)phenoxy]methyl}cyclohexane-1-carboxamide | - |
Aquifex aeolicus | |
N-hydroxy-4-methoxy-1-{[4-({4-[(morpholin-4-yl)methyl]phenyl}ethynyl)phenoxy]methyl}cyclohexane-1-carboxamide | - |
Escherichia coli | |
N-hydroxy-4-methoxy-1-{[4-({4-[(morpholin-4-yl)methyl]phenyl}ethynyl)phenoxy]methyl}cyclohexane-1-carboxamide | - |
Pseudomonas aeruginosa | |
N-hydroxy-4-[(4-{4-[2-(morpholin-4-yl)ethyl]piperazin-1-yl}phenoxy)methyl]oxane-4-carboxamide | - |
Aquifex aeolicus | |
N-hydroxy-4-[(4-{4-[2-(morpholin-4-yl)ethyl]piperazin-1-yl}phenoxy)methyl]oxane-4-carboxamide | - |
Escherichia coli | |
N-hydroxy-4-[(4-{4-[2-(morpholin-4-yl)ethyl]piperazin-1-yl}phenoxy)methyl]oxane-4-carboxamide | - |
Pseudomonas aeruginosa | |
N-hydroxy-4-[(4-{[4-({4-[2-(1H-imidazol-1-yl)ethyl]piperazin-1-yl}methyl)phenyl]ethynyl}phenoxy)methyl]oxane-4-carboxamide | - |
Aquifex aeolicus | |
N-hydroxy-4-[(4-{[4-({4-[2-(1H-imidazol-1-yl)ethyl]piperazin-1-yl}methyl)phenyl]ethynyl}phenoxy)methyl]oxane-4-carboxamide | - |
Escherichia coli | |
N-hydroxy-4-[(4-{[4-({4-[2-(1H-imidazol-1-yl)ethyl]piperazin-1-yl}methyl)phenyl]ethynyl}phenoxy)methyl]oxane-4-carboxamide | - |
Pseudomonas aeruginosa | |
N-hydroxy-4-[(4-{[4-({4-[2-(morpholin-4-yl)-2-oxoethyl]piperazin-1-yl}methyl)phenyl]ethynyl}phenoxy)methyl]oxane-4-carboxamide | - |
Aquifex aeolicus | |
N-hydroxy-4-[(4-{[4-({4-[2-(morpholin-4-yl)-2-oxoethyl]piperazin-1-yl}methyl)phenyl]ethynyl}phenoxy)methyl]oxane-4-carboxamide | - |
Escherichia coli | |
N-hydroxy-4-[(4-{[4-({4-[2-(morpholin-4-yl)-2-oxoethyl]piperazin-1-yl}methyl)phenyl]ethynyl}phenoxy)methyl]oxane-4-carboxamide | - |
Pseudomonas aeruginosa | |
N-hydroxy-4-[(4-{[4-({4-[2-(morpholin-4-yl)ethyl]piperazin-1-yl}methyl)phenyl]ethynyl}phenoxy)methyl]oxane-4-carboxamide | - |
Aquifex aeolicus | |
N-hydroxy-4-[(4-{[4-({4-[2-(morpholin-4-yl)ethyl]piperazin-1-yl}methyl)phenyl]ethynyl}phenoxy)methyl]oxane-4-carboxamide | - |
Escherichia coli | |
N-hydroxy-4-[(4-{[4-({4-[2-(morpholin-4-yl)ethyl]piperazin-1-yl}methyl)phenyl]ethynyl}phenoxy)methyl]oxane-4-carboxamide | - |
Pseudomonas aeruginosa | |
N-hydroxy-4-[(4-{[4-({[(4-methoxyphenyl)methyl]amino}methyl)phenyl]ethynyl}phenoxy)methyl]oxane-4-carboxamide | - |
Aquifex aeolicus | |
N-hydroxy-4-[(4-{[4-({[(4-methoxyphenyl)methyl]amino}methyl)phenyl]ethynyl}phenoxy)methyl]oxane-4-carboxamide | - |
Escherichia coli | |
N-hydroxy-4-[(4-{[4-({[(4-methoxyphenyl)methyl]amino}methyl)phenyl]ethynyl}phenoxy)methyl]oxane-4-carboxamide | - |
Pseudomonas aeruginosa | |
N-hydroxy-4-{[4-({4-[(4-methylpiperazin-1-yl)methyl]phenyl}ethynyl)phenoxy]methyl}oxane-4-carboxamide | - |
Aquifex aeolicus | |
N-hydroxy-4-{[4-({4-[(4-methylpiperazin-1-yl)methyl]phenyl}ethynyl)phenoxy]methyl}oxane-4-carboxamide | - |
Escherichia coli | |
N-hydroxy-4-{[4-({4-[(4-methylpiperazin-1-yl)methyl]phenyl}ethynyl)phenoxy]methyl}oxane-4-carboxamide | - |
Pseudomonas aeruginosa | |
N-hydroxy-4-{[4-({4-[(morpholin-4-yl)methyl]phenyl}ethynyl)benzene-1-sulfinyl]methyl}oxane-4-carboxamide | - |
Aquifex aeolicus | |
N-hydroxy-4-{[4-({4-[(morpholin-4-yl)methyl]phenyl}ethynyl)benzene-1-sulfinyl]methyl}oxane-4-carboxamide | - |
Escherichia coli | |
N-hydroxy-4-{[4-({4-[(morpholin-4-yl)methyl]phenyl}ethynyl)benzene-1-sulfinyl]methyl}oxane-4-carboxamide | - |
Pseudomonas aeruginosa | |
N-hydroxy-4-{[4-({4-[(morpholin-4-yl)methyl]phenyl}ethynyl)phenoxy]methyl}oxane-4-carboxamide | - |
Aquifex aeolicus | |
N-hydroxy-4-{[4-({4-[(morpholin-4-yl)methyl]phenyl}ethynyl)phenoxy]methyl}oxane-4-carboxamide | - |
Escherichia coli | |
N-hydroxy-4-{[4-({4-[(morpholin-4-yl)methyl]phenyl}ethynyl)phenoxy]methyl}oxane-4-carboxamide | - |
Pseudomonas aeruginosa | |
N-[(2S,3R)-3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl]-4-({4-[(morpholin-4-yl)methyl]phenyl}ethynyl)benzamide | - |
Aquifex aeolicus | |
N-[(2S,3R)-3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl]-4-({4-[(morpholin-4-yl)methyl]phenyl}ethynyl)benzamide | - |
Escherichia coli | |
N-[(2S,3R)-3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl]-4-({4-[(morpholin-4-yl)methyl]phenyl}ethynyl)benzamide | - |
Pseudomonas aeruginosa | |
RS-130830 | - |
Aquifex aeolicus | |
RS-130830 | - |
Escherichia coli | |
RS-130830 | - |
Pseudomonas aeruginosa |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-3-O-[(3R)-3-hydroxymyristoyl]-N-acetyl-alpha-D-glucosamine + H2O | Escherichia coli | - |
UDP-3-O-[(3R)-3-hydroxymyristoyl]-alpha-D-glucosamine + acetate | - |
r | |
UDP-3-O-[(3R)-3-hydroxymyristoyl]-N-acetyl-alpha-D-glucosamine + H2O | Pseudomonas aeruginosa | - |
UDP-3-O-[(3R)-3-hydroxymyristoyl]-alpha-D-glucosamine + acetate | - |
r | |
UDP-3-O-[(3R)-3-hydroxymyristoyl]-N-acetyl-alpha-D-glucosamine + H2O | Aquifex aeolicus | - |
UDP-3-O-[(3R)-3-hydroxymyristoyl]-alpha-D-glucosamine + acetate | - |
r | |
UDP-3-O-[(3R)-3-hydroxymyristoyl]-N-acetyl-alpha-D-glucosamine + H2O | Escherichia coli W3110 / ATCC 27325 | - |
UDP-3-O-[(3R)-3-hydroxymyristoyl]-alpha-D-glucosamine + acetate | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Aquifex aeolicus | O67648 | gene lpxC | - |
Escherichia coli | - |
gene lpxC | - |
Escherichia coli W3110 / ATCC 27325 | - |
gene lpxC | - |
Pseudomonas aeruginosa | - |
gene lpxC | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-3-O-[(3R)-3-hydroxymyristoyl]-N-acetyl-alpha-D-glucosamine + H2O | - |
Escherichia coli | UDP-3-O-[(3R)-3-hydroxymyristoyl]-alpha-D-glucosamine + acetate | - |
r | |
UDP-3-O-[(3R)-3-hydroxymyristoyl]-N-acetyl-alpha-D-glucosamine + H2O | - |
Pseudomonas aeruginosa | UDP-3-O-[(3R)-3-hydroxymyristoyl]-alpha-D-glucosamine + acetate | - |
r | |
UDP-3-O-[(3R)-3-hydroxymyristoyl]-N-acetyl-alpha-D-glucosamine + H2O | - |
Aquifex aeolicus | UDP-3-O-[(3R)-3-hydroxymyristoyl]-alpha-D-glucosamine + acetate | - |
r | |
UDP-3-O-[(3R)-3-hydroxymyristoyl]-N-acetyl-alpha-D-glucosamine + H2O | - |
Aquifex aeolicus | UDP-3-O-[(3R)-3-hydroxymyristoyl]-alpha-D-glucosamine + acetate | the product diphosphate group covalently links to the glucosamine directly interacted with Lys227 and a protein loop between beta6' and alpha2' of domain II | r | |
UDP-3-O-[(3R)-3-hydroxymyristoyl]-N-acetyl-alpha-D-glucosamine + H2O | - |
Escherichia coli W3110 / ATCC 27325 | UDP-3-O-[(3R)-3-hydroxymyristoyl]-alpha-D-glucosamine + acetate | - |
r |
Synonyms | Comment | Organism |
---|---|---|
LpxC | - |
Escherichia coli |
LpxC | - |
Pseudomonas aeruginosa |
LpxC | - |
Aquifex aeolicus |
UDP-3-O-(acyl)-N-acetylglucosamine deacetylase | - |
Escherichia coli |
UDP-3-O-(acyl)-N-acetylglucosamine deacetylase | - |
Pseudomonas aeruginosa |
UDP-3-O-(acyl)-N-acetylglucosamine deacetylase | - |
Aquifex aeolicus |
General Information | Comment | Organism |
---|---|---|
additional information | cocrystal structure of Aquifex aeolicus LpxC with bound UDP-3-O-(acyl)-glucosamine and Pseudomonas aeruginosa with bound 27b docking model, overview | Pseudomonas aeruginosa |
additional information | cocrystal structure of Aquifex aeolicus LpxC with bound UDP-3-O-(acyl)-glucosamine and Pseudomonas. aeruginosa with bound 27b docking model, overview | Aquifex aeolicus |