Literature summary for 3.5.1.104 extracted from

Kaoukab-Raji, A.; Biskri, L.; Bernardini, M.L.; Allaoui, A.
Characterization of SfPgdA, a Shigella flexneri peptidoglycan deacetylase required for bacterial persistence within polymorphonuclear neutrophils (2012), Microbes Infect., 14, 619-627.

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Protein Variants

Protein Variants	Comment	Organism
H120F	mutation impairs enzymic function	Shigella flexneri
H125F	mutation impairs enzymic function	Shigella flexneri
L222V	mutant exhibits sensitivity to lysozyme similar to wild-type, acticity is similar to wild-type	Shigella flexneri

Organism

Organism	UniProt	Comment	Textmining
Shigella flexneri	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining

Synonyms

Synonyms	Comment	Organism
SfPgdA	-	Shigella flexneri

Expression

Organism	Comment	Expression
Shigella flexneri	SfPgdA expression is controlled by PhoP, a phoP mutant does not produce SfPgdA, which results in increased sensitivity to lysozyyme	down
Shigella flexneri	SfPgdA expression is enhanced under low magnesium concentration	up

General Information

General Information	Comment	Organism
physiological function	inactivation of SfpgdA enhances Shigella sensitivity to lysozyme. Peptidoglycan purified from the SfpgdA mutant is sensitive to degradation by lysozyme, and the mutant is rapidly killed by polymorphonuclear neutrophils	Shigella flexneri

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Release 2023.1 (January 2023)