Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-[[4-(diethylamino)-2-hydroxyphenyl]carbonyl]benzoic acid | 1 mM, 7% residual activity | Streptococcus pneumoniae | |
N-(3-acetylphenyl)-2-[2-(hydrazinylcarbonothioyl)hydrazinyl]-2-(1-oxido-3-oxo-3,4-dihydro-2H-1,4-benzothiazin-2-yl)acetamide | 1 mM, 29% residual activity | Streptococcus pneumoniae |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
2.27 | - |
4-yethylumbelliferyl acetate | 37°C, pH 7.0 | Streptococcus pneumoniae | |
2.38 | - |
4-yethylumbelliferyl acetate | 37°C, pH 8.0 | Streptococcus pneumoniae | |
16.7 | - |
4-nitrophenyl acetate | 37°C, pH 7.0 | Streptococcus pneumoniae |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Streptococcus pneumoniae | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-methylumbelliferyl acetate + H2O | - |
Streptococcus pneumoniae | 4-methylumbelliferol + acetate | - |
? | |
4-nitrophenyl acetate + H2O | - |
Streptococcus pneumoniae | 4-nitrophenol + acetate | - |
? | |
acetylated peptidoglycan + H2O | - |
Streptococcus pneumoniae | deacetylated peptidoglycan + acetate | - |
? | |
additional information | enzyme is inactive against peptidoglycans from Staphylococcus aureus, Staphylococcus carnosus or Escherichia coli. No substrate: N-acetylglucosamine | Streptococcus pneumoniae | ? | - |
? | |
N,N',N'',N''',N''''-pentaacetylchitopentaose + H2O | - |
Streptococcus pneumoniae | N,N',N''-triacetylchitopentaose + N,N'-diacetylchitopentaose + N-acetylchitopentaose + acetate | almost quantitative conversion to mono-, di- and tri-de-acetylated products | ? | |
peptidoglycan from Streptococcus suis + H2O | - |
Streptococcus pneumoniae | deacetylated peptidoglycan + acetate | - |
? | |
peptidoglycan from wild-type Streptococcus pneumoniae + H2O | - |
Streptococcus pneumoniae | deacetylated peptidoglycan + acetate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
pgdA | - |
Streptococcus pneumoniae |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.28 | - |
4-yethylumbelliferyl acetate | 37°C, pH 7.0 | Streptococcus pneumoniae | |
0.46 | - |
4-nitrophenyl acetate | 37°C, pH 7.0 | Streptococcus pneumoniae | |
1.64 | - |
4-yethylumbelliferyl acetate | 37°C, pH 8.0 | Streptococcus pneumoniae |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.13 | - |
37°C, pH 7.0 | Streptococcus pneumoniae | 2-[[4-(diethylamino)-2-hydroxyphenyl]carbonyl]benzoic acid | |
0.584 | - |
37°C, pH 7.0 | Streptococcus pneumoniae | N-(3-acetylphenyl)-2-[2-(hydrazinylcarbonothioyl)hydrazinyl]-2-(1-oxido-3-oxo-3,4-dihydro-2H-1,4-benzothiazin-2-yl)acetamide |
kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0288 | - |
4-nitrophenyl acetate | 37°C, pH 7.0 | Streptococcus pneumoniae | |
0.129 | - |
4-yethylumbelliferyl acetate | 37°C, pH 7.0 | Streptococcus pneumoniae | |
0.71 | - |
4-yethylumbelliferyl acetate | 37°C, pH 8.0 | Streptococcus pneumoniae |