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Literature summary for 3.5.1.104 extracted from

  • Davis, K.M.; Akinbi, H.T.; Standish, A.J.; Weiser, J.N.
    Resistance to mucosal lysozyme compensates for the fitness deficit of peptidoglycan modifications by Streptococcus pneumoniae (2008), PLoS Pathog., 4, e1000241.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.5.1.104

Application

Application Comment Organism
pharmacology studies on peptidoglycan modifications by Streptococcus pneumoniae Streptococcus pneumoniae

Cloned(Commentary)

Cloned (Comment) Organism
generation of mutant (pgdA and pgdAadr) and revertant strains Streptococcus pneumoniae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetylated peptidoglycan + H2O Streptococcus pneumoniae
-
 deacetylated peptidoglycan + acetate
-
 ?

Organism

Organism UniProt Comment Textmining
Streptococcus pneumoniae A0A0H2UQQ3 wild-type and pgdA mutant strains (pgdA and pgdAadr)
-

Source Tissue

Source Tissue Comment Organism Textmining
nasopharynx peptidoglycan modifications during colonizing the mucosal surface of the upper respiratory tract, lysozyme M-sufficient mice Streptococcus pneumoniae
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 competition experiments with wild-type and mutant strains in lysozyme M-sufficient mice, effect of peptidoglycan modifying enzymes on growth, viability and hydrolysis of pneumococcal cell walls as well as on relative fitness during murine colonization in the presence or absence of lysozyme shown, contribution of lysozyme from neutrophils to survival and colonization of mutants lacking peptidoglycan modifications, effect of peptidoglycan modifying enzymes on expression of capsular polysaccharide (CPS) Streptococcus pneumoniae

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetylated peptidoglycan + H2O
-
 Streptococcus pneumoniae deacetylated peptidoglycan + acetate
-
 ?
acetylated peptidoglycan + H2O contribution of lysozyme and peptidoglycan modifications during colonization of the upper respiratory tract analyzed Streptococcus pneumoniae deacetylated peptidoglycan + acetate
-
 ?

Synonyms

Synonyms Comment Organism
N-acetylglucosamine deacetylase
-
 Streptococcus pneumoniae
pgdA
-
 Streptococcus pneumoniae