Application | Comment | Organism |
---|---|---|
pharmacology | studies on peptidoglycan modifications by Streptococcus pneumoniae | Streptococcus pneumoniae |
Cloned (Comment) | Organism |
---|---|
generation of mutant (pgdA and pgdAadr) and revertant strains | Streptococcus pneumoniae |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetylated peptidoglycan + H2O | Streptococcus pneumoniae | - |
deacetylated peptidoglycan + acetate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Streptococcus pneumoniae | A0A0H2UQQ3 | wild-type and pgdA mutant strains (pgdA and pgdAadr) | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
nasopharynx | peptidoglycan modifications during colonizing the mucosal surface of the upper respiratory tract, lysozyme M-sufficient mice | Streptococcus pneumoniae | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
competition experiments with wild-type and mutant strains in lysozyme M-sufficient mice, effect of peptidoglycan modifying enzymes on growth, viability and hydrolysis of pneumococcal cell walls as well as on relative fitness during murine colonization in the presence or absence of lysozyme shown, contribution of lysozyme from neutrophils to survival and colonization of mutants lacking peptidoglycan modifications, effect of peptidoglycan modifying enzymes on expression of capsular polysaccharide (CPS) | Streptococcus pneumoniae |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetylated peptidoglycan + H2O | - |
Streptococcus pneumoniae | deacetylated peptidoglycan + acetate | - |
? | |
acetylated peptidoglycan + H2O | contribution of lysozyme and peptidoglycan modifications during colonization of the upper respiratory tract analyzed | Streptococcus pneumoniae | deacetylated peptidoglycan + acetate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
N-acetylglucosamine deacetylase | - |
Streptococcus pneumoniae |
pgdA | - |
Streptococcus pneumoniae |