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Literature summary for 3.5.1.104 extracted from
- Inactivation of the wall-associated de-N-acetylase (PgdA) of Listeria monocytogenes results in greater susceptibility of the cells to induced autolysis (2009), J. Microbiol. Biotechnol., 19, 932-945.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cell wall | - |
Listeria monocytogenes | 5618 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| peptidoglycan-N-acetyl-D-glucosamine + H2O | Listeria monocytogenes | peptidoglycan N-deacetylation is an important modification of Listeria peptidoglycan, which allows this human pathogen to evade the innate immune system | peptidoglycan-D-glucosamine + acetate | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Listeria monocytogenes | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| hexa-His-tagged form of PgdA | Listeria monocytogenes |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | N-acetylmuramic acid is not a substrate. With N-acetylglucosamine as substrate D-glucosamine is formed | Listeria monocytogenes | ? | - |
? | |
| peptidoglycan-N-acetyl-D-glucosamine + H2O | peptidoglycan N-deacetylation is an important modification of Listeria peptidoglycan, which allows this human pathogen to evade the innate immune system | Listeria monocytogenes | peptidoglycan-D-glucosamine + acetate | - |
? | |
| peptidoglycan-N-acetyl-D-glucosamine + H2O | N-acetylated murein after lysozyme digestion | Listeria monocytogenes | peptidoglycan-D-glucosamine + acetate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Lmo0415 | - |
Listeria monocytogenes |
| peptidoglycan N-acetylglucosamine deacetylase | - |
Listeria monocytogenes |
| pgdA | - |
Listeria monocytogenes |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | inactivation of the wall-associated de-N-acetylase results in greater susceptibility of the cells to induced autolysis | Listeria monocytogenes |
| physiological function | peptidoglycan N-deacetylation is an important modification of Listeria peptidoglycan, which allows this human pathogen to evade the innate immune system | Listeria monocytogenes |
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Release 2023.1 (January 2023)
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