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Literature summary for 3.5.1.104 extracted from
- Oxidative stress-induced peptidoglycan deacetylase in Helicobacter pylori (2009), J. Biol. Chem., 284, 6790-6800.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| peptidoglycan-N-acetyl-D-glucosamine + H2O | Helicobacter pylori | Helicobacter pylori is highly resistant to lysozyme (up to 50 mg/ml), but the HP310 mutant is less resistant compared with the parent strain. The peptidoglycan deacetylation appears to confer lysozyme resistance to escape immunedetection | peptidoglycan-D-glucosamine + acetate | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Helicobacter pylori | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| peptidoglycan-N-acetyl-D-glucosamine + H2O | - |
Helicobacter pylori | peptidoglycan-D-glucosamine + acetate | - |
? | |
| peptidoglycan-N-acetyl-D-glucosamine + H2O | Helicobacter pylori is highly resistant to lysozyme (up to 50 mg/ml), but the HP310 mutant is less resistant compared with the parent strain. The peptidoglycan deacetylation appears to confer lysozyme resistance to escape immunedetection | Helicobacter pylori | peptidoglycan-D-glucosamine + acetate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| HP310 | - |
Helicobacter pylori |
| peptidoglycan deacetylase | - |
Helicobacter pylori |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Helicobacter pylori | HP310 is markedly up-expressed upon cell exposure to oxidative stress | up |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | Helicobacter pylori is highly resistant to lysozyme (up to 50 mg/ml), but the HP310 mutant is less resistant compared with the parent strain. The peptidoglycan deacetylation appears to confer lysozyme resistance to escape immunedetection | Helicobacter pylori |
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