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Literature summary for 3.5.1.103 extracted from

  • Newton, G.L.; Av-Gay, Y.; Fahey, R.C.
    N-Acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase (MshB) is a key enzyme in mycothiol biosynthesis (2000), J. Bacteriol., 182, 6958-6963.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol + H2O Mycobacterium tuberculosis
-
 1-(2-amino-2-deoxy-alpha-D-glucopyranoside)-1D-myo-inositol + acetate
-
 ?
1-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol + H2O Mycobacterium tuberculosis mycothiol biosynthesis 1-(2-amino-2-deoxy-alpha-D-glucopyranoside)-1D-myo-inositol + acetate
-
 ?
1-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol + H2O Mycobacterium tuberculosis H37Rv
-
 1-(2-amino-2-deoxy-alpha-D-glucopyranoside)-1D-myo-inositol + acetate
-
 ?
1-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol + H2O Mycobacterium tuberculosis H37Rv mycothiol biosynthesis 1-(2-amino-2-deoxy-alpha-D-glucopyranoside)-1D-myo-inositol + acetate
-
 ?

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis P9WJN3
-
-
Mycobacterium tuberculosis H37Rv P9WJN3
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol + H2O
-
 Mycobacterium tuberculosis 1-(2-amino-2-deoxy-alpha-D-glucopyranoside)-1D-myo-inositol + acetate
-
 ?
1-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol + H2O mycothiol biosynthesis Mycobacterium tuberculosis 1-(2-amino-2-deoxy-alpha-D-glucopyranoside)-1D-myo-inositol + acetate
-
 ?
1-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol + H2O activity with 1-D-myo-inosityl-2-acetamido-2-deoxy-alpha-D-glucopyranoside as the substrate is over 300fold greater than the deacetylase activity determined with N-acety-D-glucosamine and 23fold greater than the amidase activity measured with MSmB Mycobacterium tuberculosis 1-(2-amino-2-deoxy-alpha-D-glucopyranoside)-1D-myo-inositol + acetate
-
 ?
1-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol + H2O
-
 Mycobacterium tuberculosis H37Rv 1-(2-amino-2-deoxy-alpha-D-glucopyranoside)-1D-myo-inositol + acetate
-
 ?
1-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol + H2O mycothiol biosynthesis Mycobacterium tuberculosis H37Rv 1-(2-amino-2-deoxy-alpha-D-glucopyranoside)-1D-myo-inositol + acetate
-
 ?
1-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol + H2O activity with 1-D-myo-inosityl-2-acetamido-2-deoxy-alpha-D-glucopyranoside as the substrate is over 300fold greater than the deacetylase activity determined with N-acety-D-glucosamine and 23fold greater than the amidase activity measured with MSmB Mycobacterium tuberculosis H37Rv 1-(2-amino-2-deoxy-alpha-D-glucopyranoside)-1D-myo-inositol + acetate
-
 ?
N-acetyl-D-glucosamine + H2O activity is 300fold lower than with 1-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol Mycobacterium tuberculosis D-glucosamine + acetate
-
 ?
N-acetyl-D-glucosamine + H2O activity is 300fold lower than with 1-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol Mycobacterium tuberculosis H37Rv D-glucosamine + acetate
-
 ?

Synonyms

Synonyms Comment Organism
MshB
-
 Mycobacterium tuberculosis
N-acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase
-
 Mycobacterium tuberculosis
Rv1170
-
 Mycobacterium tuberculosis

General Information

General Information Comment Organism
malfunction GlcNAc-Ins is absent in mycothiol-deficient mutant strain 49. This strain can concentrate GlcNAc-Ins from the medium and convert it to mycothiol Mycobacterium tuberculosis