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Literature summary for 3.5.1.1 extracted from

  • Wriston, J.C.
    L-Asparaginase (1971), The Enzymes, 3rd Ed. (Boyer, P. D. , ed. ), 4, 101-121.
No PubMed abstract available

Application

Application Comment Organism
medicine enzyme has antitumor activity Cavia porcellus
medicine enzyme has antitumor activity Escherichia coli
medicine enzyme has antitumor activity Serratia marcescens
medicine enzyme has antitumor activity Pectobacterium carotovorum
medicine enzyme has antitumor activity Erwinia aroidea

General Stability

General Stability Organism
stable to dialysis in the cold, but labile under conditions which promote surface denaturation Cavia porcellus
stable to repeated freezing and thawing Cavia porcellus

Inhibitors

Inhibitors Comment Organism Structure
5-Diazo-4-oxo-L-norvaline
-
Escherichia coli
Dimethylsulfoxide
-
Escherichia coli
Hg2+
-
Cavia porcellus
NH4+ product inhibition at pH 8.5 Escherichia coli
p-mercuribenzoate
-
Cavia porcellus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information
-
Cavia porcellus
additional information
-
additional information
-
Weizmannia coagulans

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
additional information
-
-
Escherichia coli
85000
-
sucrose density gradient centrifugation Weizmannia coagulans
128000 145000
-
Pectobacterium carotovorum
133000
-
gel filtration Cavia porcellus
138000
-
ultracentrifugation Cavia porcellus
150000
-
sucrose density gradient centrifugation Serratia marcescens
160000 171000 sucrose density gradient centrifugation Fusarium tricinctum

Organism

Organism UniProt Comment Textmining
Cavia porcellus
-
-
-
Erwinia aroidea
-
-
-
Escherichia coli
-
-
-
Fusarium tricinctum
-
-
-
Pectobacterium carotovorum
-
-
-
Serratia marcescens
-
-
-
Weizmannia coagulans
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Escherichia coli

Renatured (Commentary)

Renatured (Comment) Organism
urea denaturation is irreversible Weizmannia coagulans
urea denaturation is reversible Escherichia coli
urea denaturation is reversible Serratia marcescens

Source Tissue

Source Tissue Comment Organism Textmining
serum
-
Cavia porcellus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
beta-cyano-L-Ala + H2O
-
Cavia porcellus ?
-
?
beta-cyano-L-Ala + H2O
-
Escherichia coli ?
-
?
beta-cyano-L-Ala + H2O
-
Pectobacterium carotovorum ?
-
?
D-Asn + H2O
-
Escherichia coli D-Asp + NH3
-
?
D-Asn + H2O
-
Weizmannia coagulans D-Asp + NH3
-
?
D-Asn + H2O
-
Pectobacterium carotovorum D-Asp + NH3
-
?
D-Asn + H2O 3% of the activity with L-Asn Cavia porcellus D-Asp + NH3
-
?
L-Asn + H2O
-
Cavia porcellus L-Asp + NH3
-
?
L-Asn + H2O
-
Escherichia coli L-Asp + NH3
-
?
L-Asn + H2O
-
Serratia marcescens L-Asp + NH3
-
?
L-Asn + H2O
-
Weizmannia coagulans L-Asp + NH3
-
?
L-Asn + H2O
-
Pectobacterium carotovorum L-Asp + NH3
-
?
L-Asn + H2O
-
Erwinia aroidea L-Asp + NH3
-
?
L-Asn + H2O
-
Fusarium tricinctum L-Asp + NH3
-
?
L-Asp + H2O
-
Escherichia coli ?
-
?
L-Gln + H2O
-
Escherichia coli L-Glu + NH3
-
?
L-Gln + H2O
-
Pectobacterium carotovorum L-Glu + NH3
-
?
L-leucine amide + H2O 5.3% of the activity with L-Asn Cavia porcellus ?
-
?
L-phenylalanine amide + H2O 8.2% of the activity with L-Asn Cavia porcellus ?
-
?
additional information enzyme has no antitumor activity Weizmannia coagulans ?
-
?
additional information enzyme has no antitumor activity Fusarium tricinctum ?
-
?
additional information enzyme has antitumor activity Cavia porcellus ?
-
?
additional information enzyme has antitumor activity Escherichia coli ?
-
?
additional information enzyme has antitumor activity Serratia marcescens ?
-
?
additional information enzyme has antitumor activity Pectobacterium carotovorum ?
-
?
additional information enzyme has antitumor activity Erwinia aroidea ?
-
?

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
55
-
10 min, stable Cavia porcellus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.9
-
broad Serratia marcescens
7.5
-
-
Erwinia aroidea
7.5 8.5
-
Cavia porcellus
7.5 8.7
-
Fusarium tricinctum
8
-
broad Escherichia coli
8.5 9.5
-
Weizmannia coagulans