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Literature summary for 3.4.99.B1 extracted from

  • Burrows, J.F.; Kelvin, A.A.; McFarlane, C.; Burden, R.E.; McGrattan, M.J.; De la Vega, M.; Govender, U.; Quinn, D.J.; Dib, K.; Gadina, M.; Scott, C.J.; Johnston, J.A.
    USP17 regulates Ras activation and cell proliferation by blocking RCE1 activity (2009), J. Biol. Chem., 284, 9587-9595.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.99.B1

Inhibitors

Inhibitors Comment Organism Structure
USP17 USP17 deubiquitinates RCE1 and negatively regulates the activity of RCE1. Constitutive expression of USP17 blocks cell growth and decreases Ras activation, knockdown of USP17 expression results in a marked elevation in the level of GTP-bound Ras. USP17 and RCE1 co-localize at the endoplasmic reticulum Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum membrane RCE1 colocalizes with USP17 in the endoplasmic reticulum Homo sapiens 5789
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Posttranslational Modification

Posttranslational Modification Comment Organism
additional information RCE1 is regulated by ubiquination, deubiquitinating enzyme USP17 negatively regulates the activity of RCE1, overview Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
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 Homo sapiens
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Synonyms

Synonyms Comment Organism
Ras-converting enzyme 1
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 Homo sapiens
RCE1
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 Homo sapiens

General Information

General Information Comment Organism
metabolism the deubiquitinating enzyme USP17 negatively regulates the activity of RCE1 Homo sapiens
physiological function RCE1 is involved in Ras trafficking to the plasma membrane and the Ras/MEK/ERK pathway. USP17 regulation of growth is RCE1-dependent, overview Homo sapiens