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Literature summary for 3.4.99.B1 extracted from

  • Bergo, M.O.; Lieu, H.D.; Gavino, B.J.; Ambroziak, P.; Otto, J.C.; Casey, P.J.; Walker, Q.M.; Young, S.G.
    On the physiological importance of endoproteolysis of CAAX proteins: heart-specific RCE1 knockout mice develop a lethal cardiomyopathy (2004), J. Biol. Chem., 279, 4729-4736.
    View publication on PubMed

Application

Application Comment Organism
medicine Rce1 knockout mice have a dilated cardiomyopathy, by contrast, liver-specific Rce1 knockout mice appear healthy, endoproteolytic processing of CAAX proteins is essential for cardiac function but less important for the liver Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information heart specific and liver specific Rce1 knockout mice Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum
-
Mus musculus 5783
-
membrane
-
Mus musculus 16020
-
additional information fibroblast Mus musculus
-
-

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
Mus musculus
-
liver
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
a-factor-CaaX + H2O
-
Mus musculus a-factor-C + aaX
-
?

Synonyms

Synonyms Comment Organism
RCE1
-
Mus musculus