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Literature summary for 3.4.25.2 extracted from

  • Rohrwild, M.; Coux, O.; Huang, H.C.; Moerschell, R.P.; Yoo, S.J.; Seol, J.H.; Chung, C.H.; Goldberg, A.L.
    HslV-HslU: A novel ATP-dependent protease complex in Escherichia coli related to the eukaryotic proteasome (1996), Proc. Natl. Acad. Sci. USA, 93, 5808-5813.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.25.2

Inhibitors

Inhibitors Comment Organism Structure
3,4-dichloroisocoumarin 0.2 mM, 50% inhibition Escherichia coli
acety-Leu-Leu-norleucinal 0.01 mM, 90% inhibition Escherichia coli
ADP when added together with ATP Escherichia coli
benzyloxycarbonyl-Leu-Leu-norleucinal 0.01 mM, 97% inhibition Escherichia coli
lactacystin 0.1 mM, 24% inhibition Escherichia coli
NEM 0.1 mM, 62% inhibition Escherichia coli
phenylmethylsulfonyl fluoride 1 mM, 10% inhibition Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
benzyloxycarbonyl-GGL-7-amido-4-methylcoumarin + H2O
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 Escherichia coli benzyloxycarbonyl-GGL + 7-amino-4-methylcoumarin
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 ?
additional information less than 1% of the activity with benzyloxycarbonyl-GGL-7-amido-4-methylcoumarin is observed with succinyl-AAF-7-amido-4-methylcoumarin and succinyl-LLVY-7-amido-4-methylcoumarin. No activity with benzoyl-RGFFL-4-methoxy-beta-naphthylamide, glutaryl-AAA-4-methoxy-beta-naphthylamide, benzyloxycarbonyl-LLE-4-methoxy-beta-naphthylamide, succinyl-FLF-beta-naphthylamide, succinyl-LY-7-amido-4-methylcoumarin, benzoyl-GP-7-amido-4-methylcoumarin, acetyl-YVAA-7-amido-4-methylcoumarin, tert-butyloxycarbonyl-LRR-7-amido-4-methylcoumarin, t-butyloxycarbonyl-FVR-7-amido-4-methylcoumarin, benzoyl-GGR-7-amido-4-methylcoumarin, benzoyl-Arg-7-amido-4-methylcoumarin Escherichia coli ?
-
 ?

Cofactor

Cofactor Comment Organism Structure
ATP ATP activates hydrolysis of benzyloxycarbonyl-GGL-7-amido-4-methylcoumarin 150fold Escherichia coli