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Literature summary for 3.4.25.1 extracted from

  • Witkowska, J.; Gizynska, M.; Grudnik, P.; Golik, P.; Karpowicz, P.; Gieldon, A.; Dubin, G.; Jankowska, E.
    Crystal structure of a low molecular weight activator Blm-pep with yeast 20S proteasome - insights into the enzyme activation mechanism (2017), Sci. Rep., 7, 6177 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.25.1

Activating Compound

Activating Compound Comment Organism Structure
KYFTGSKLWRSYYA peptidic activator, based on the Blm10 activator of 20S proteasome. At 10 microM concentration, chymotrypsin-like and peptidylglutamyl peptide hydrolyzing activities increase around three times whereas trypsin-like activity increases around 7fold Homo sapiens

Crystallization (Commentary)

Crystallization (Comment) Organism
in complex with peptide KYFTGSKLWRSYYA, to 3 A resolution Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
erythrocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Boc-Leu-Leu-Glu-4-methylcoumarin-7-amide + H2O
-
 Homo sapiens Boc-Leu-Leu-Glu + 7-amino-4-methylcoumarin
-
 ?
succinyl-Leu-Leu-Val-Tyr-4-methylcoumarin-7-amide + H2O
-
 Homo sapiens succinyl-Leu-Leu-Val-Tyr + 7-amino-4-methylcoumarin
-
 ?
tert-butyloxycarbonyl-Leu-Arg-Arg-4-methylcoumarin-7-amide
-
 Homo sapiens ?
-
 ?