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Literature summary for 3.4.25.1 extracted from
- Progress curve analysis of the kinetics of slow-binding anticancer drug inhibitors of the 20S proteasome (2018), Arch. Biochem. Biophys., 639, 52-58 .
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| bortezomib | slow-binding inhibitor, kinetic analysis | Homo sapiens |  |
| delanzomib | slow-binding inhibitor, kinetic analysis | Homo sapiens | |
| ixazomib | slow-binding inhibitor, kinetic analysis | Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| succinyl-Leu-Leu-Val-Tyr-7-amido-4-methylcoumarin + H2O | - |
Homo sapiens | succinyl-Leu-Leu-Val-Tyr + 7-amino-4-methylcoumarin | - |
? | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0000014 | - |
delanzomib | pH 8.0, 30°C | Homo sapiens | |
| 0.0000016 | - |
bortezomib | pH 8.0, 30°C | Homo sapiens | |
| 0.0000049 | - |
ixazomib | pH 8.0, 30°C | Homo sapiens | |
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