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Literature summary for 3.4.25.1 extracted from

  • Liepe, J.; Mishto, M.; Textoris-Taube, K.; Janek, K.; Keller, C.; Henklein, P.; Kloetzel, P.M.; Zaikin, A.
    The 20S proteasome splicing activity discovered by SpliceMet (2010), PLoS Comput. Biol., 6, e1000830.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
additional information peptide splicing is an intrinsic additional catalytic property of the proteasome, which may provide a qualitative peptide pool for immune selection Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
B-lymphocyte immortalized with Epstein Barr virus Homo sapiens
-
lymphoblast
-
Homo sapiens
-
T-lymphocyte
-
Homo sapiens
-

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.3
-
assay at Homo sapiens

General Information

General Information Comment Organism
additional information development of SpliceMet: a method that combines combinatorial computations with mass spectrometric analyses of proteasome-generated spliced peptides, for analysis of peptides, presented by MHC class I molecules on the cell surface, in a manner independent of cytotoxic T lymphocytes, kinetics, detailed overview Homo sapiens
physiological function the 20S proteasome, which is the major proteolytic enzyme of the cell, is responsible for the generation of antigenic peptides derived from endogenously expressed foreign or aberrant protein molecules. The proteasome-generated spliced peptides are presented by MHC class I molecules to the outside world so that they can be specifically recognised by cytotoxic T lymphocytes at the cell surface. Peptide splicing is an intrinsic additional catalytic property of the proteasome Homo sapiens