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Literature summary for 3.4.25.1 extracted from

  • Berges, C.; Haberstock, H.; Fuchs, D.; Sadeghi, M.; Opelz, G.; Daniel, V.; Naujokat, C.
    Proteasome inhibition activates the mitochondrial pathway of apoptosis in human CD4+ T cells (2009), J. Cell. Biochem., 108, 935-946.
    View publication on PubMed
Search for more literature for 3.4.25.1

Application

Application Comment Organism
medicine possible use of proteasome inhibitors for immunosuppression Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
bortezomib activates the mitochondrial pathway of apoptosis in activated CD4+ T cells by disrupting the equilibrium of pro-apoptotic and anti-apoptotic proteins at the outer mitochondrial membrane and by inducing the generation of reactive oxygen species Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
monocyte
-
 Homo sapiens
-
T-lymphocyte
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
proteasome
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Homo sapiens

General Information

General Information Comment Organism
metabolism inhibition of the proteolytic activity of the proteasome induces apoptosis and suppresses essential functions of activated human CD4+ T cells, and proteasome inhibition activates the mitochondrial pathway of apoptosis in human CD4+ T cells, detailed mechanisms of apoptosis, overview Homo sapiens