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Literature summary for 3.4.25.1 extracted from

  • Waring, J.F.; Ciurlionis, R.; Marsh, K.; Klein, L.L.; Degoey, D.A.; Randolph, J.T.; Spear, B.; Kempf, D.J.
    Identification of proteasome gene regulation in a rat model for HIV protease inhibitor-induced hyperlipidemia (2010), Arch. Toxicol., 84, 263-270.
    View publication on PubMed
Search for more literature for 3.4.25.1

Inhibitors

Inhibitors Comment Organism Structure
bortezomib
-
 Rattus norvegicus
additional information design and screening method development for protease inhibitors, that do not induce the proteasome, overview Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus the proteasome is a cylindrical, multicatalytic proteolytic machine with three peptidase activities, chymotryptic, tryptic and postglutamyl peptide hydrolytic ?
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 male sprague-dawley rats
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the proteasome is a cylindrical, multicatalytic proteolytic machine with three peptidase activities, chymotryptic, tryptic and postglutamyl peptide hydrolytic Rattus norvegicus ?
-
 ?

Expression

Organism Comment Expression
Rattus norvegicus ritonavir and A-792611 induce changes in the proteasome gene expression in rat liver, expression profiles, overview additional information