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Literature summary for 3.4.25.1 extracted from
- Tissue specific increase of the catalytic subunits of the 26S proteasome by indirect antioxidant dithiolethione in mice: enhanced activity for degradation of abnormal protein (2007), Life Sci., 80, 2411-2420.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| 3H-1,2-dithiole-3-thione | tissue specific increase of the catalytic subunits of the proteasome following oral administration of 0.5 mmol/kg | Mus musculus |  |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| MG132 | 0.02 mM | Mus musculus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| cerebral cortex | - |
Mus musculus | - |
| colon | - |
Mus musculus | - |
| hippocampus | - |
Mus musculus | - |
| liver | - |
Mus musculus | - |
| lung | - |
Mus musculus | - |
| N1E-115 cell | - |
Mus musculus | - |
| small intestine | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| succinyl-Leu-Leu-Val-Tyr-7-amido-4-methylcoumarin + H2O | - |
Mus musculus | ? | - |
? | |
| Z-Ala-Arg-Arg-7-amido-4-methylcoumarin + H2O | - |
Mus musculus | ? | - |
? | |
| Z-Leu-Leu-Glu-7-amido-4-methylcoumarin + H2O | - |
Mus musculus | Z-Leu-Leu-Glu + 7-amino-4-methylcoumarin | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 20S proteasome | - |
Mus musculus |
| 26S proteasome | - |
Mus musculus |
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