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Literature summary for 3.4.25.1 extracted from
- The 26S proteasome of the lignin-degrading basidiomycete Phlebia radiata (2007), Enzyme Microb. Technol., 40, 347-353.
No PubMed abstract available
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| clasto-lactacystin beta-lactone | complete inhibition of the chymotrypsin-like activity at 0.01 mM, complete inhibition of the trypsin-like activity at 0.02 mM, and complete inhibition of caspase-activity of the 26S proteasome at 0.02 mM | Phlebia radiata |  |
| MG132 | 31% residual chymotrypsin-like activity at 0.04 mM, 24% residual trypsin-like activity at 0.04 mM, and complete inhibition of caspase-activity of the 26S proteasome at 0.02 mM | Phlebia radiata | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Phlebia radiata | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| mycelium | - |
Phlebia radiata | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| benzyloxycarbonyl-GGR-7-amido-4-methylcoumarin + H2O | tryspin-like activity | Phlebia radiata | ? | - |
? | |
| benzyloxycarbonyl-LLE-beta-naphthylamide + H2O | caspase-like activity | Phlebia radiata | ? | - |
? | |
| succinyl-Leu-Leu-Val-Tyr-7-amido-4-methylcoumarin + H2O | chymotrypsin-like activity | Phlebia radiata | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 26S proteasome | - |
Phlebia radiata |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Phlebia radiata | |
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Release 2023.1 (January 2023)
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