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Literature summary for 3.4.25.1 extracted from

  • Milacic, V.; Chen, D.; Ronconi, L.; Landis-Piwowar, K.R.; Fregona, D.; Dou, Q.P.
    A novel anticancer gold(III) dithiocarbamate compound inhibits the activity of a purified 20S proteasome and 26S proteasome in human breast cancer cell cultures and xenografts (2006), Cancer Res., 66, 10478-10486.
    View publication on PubMed
Search for more literature for 3.4.25.1

Cloned(Commentary)

Cloned (Comment) Organism
expressed in MDA-MB-231 breast cancer cells Oryctolagus cuniculus

Inhibitors

Inhibitors Comment Organism Structure
dibromo[(dimethylamino)methanedithiolato(2-)-kappa2S1,S1]aurate(3-) proteasome inhibition and apoptosis induction are completely blocked by addition of dithiothreitol or N-acetyl-L-cysteine, showing that process of oxidation is required for proteasome inhibition Oryctolagus cuniculus
KAuBr4
-
 Oryctolagus cuniculus

Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
succinyl-Leu-Leu-Val-Tyr-7-amido-4-methylcoumarin + H2O
-
 Oryctolagus cuniculus ?
-
 ?

Synonyms

Synonyms Comment Organism
20S proteasome
-
 Oryctolagus cuniculus
26S proteasome
-
 Oryctolagus cuniculus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0074
-
 inhibition of the chymotrypsin-like activity of the 20S proteasome Oryctolagus cuniculus dibromo[(dimethylamino)methanedithiolato(2-)-kappa2S1,S1]aurate(3-)
0.0347
-
-
 Oryctolagus cuniculus KAuBr4