Literature summary for 3.4.25.1 extracted from

Tambyrajah, W.S.; Bowler, L.D.; Medina-Palazon, C.; Sinclair, A.J.
Cell cycle-dependent caspase-like activity that cleaves p27(KIP1) is the beta(1) subunit of the 20S proteasome (2007), Arch. Biochem. Biophys., 466, 186-193.

Search for more literature for 3.4.25.1

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Jurkat cells	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
acetyl-DPSD-CHO	-	Homo sapiens
Ca2+	-	Homo sapiens
K+	-	Homo sapiens
Na+	-	Homo sapiens
NH4+	-	Homo sapiens

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mg2+	enhanced by low concentrations of Mg2+ (5-15 mM)	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
Q-Sepharose HP chromatography	Homo sapiens

Source Tissue

Source Tissue	Comment	Organism	Textmining
erythrocyte	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
acetyl-DPSD-7-amido-4-methylcoumarin + H2O	cleaved by the beta1 subunit of the 20S proteasome	Homo sapiens	?	-	?
p27(KIP1) + H2O	-	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
20S proteasome	-	Homo sapiens
KIPase	-	Homo sapiens

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Release 2023.1 (January 2023)