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Literature summary for 3.4.24.B9 extracted from

  • Oksala, N.; Levula, M.; Airla, N.; Pelto-Huikko, M.; Ortiz, R.M.; Jaervinen, O.; Salenius, J.P.; Ozsait, B.; Komurcu-Bayrak, E.; Erginel-Unaltuna, N.; Huovila, A.P.; Kytoemaeki, L.; Soini, J.T.; Kaehoenen, M.; Karhunen, P.J.; Laaksonen, R.; Lehtimaeki, T.
    ADAM-9, ADAM-15, and ADAM-17 are upregulated in macrophages in advanced human atherosclerotic plaques in aorta and carotid and femoral arteries--Tampere vascular study (2009), Ann. Med., 41, 279-290.
    View publication on PubMed
Search for more literature for 3.4.24.B9

Cloned(Commentary)

Cloned (Comment) Organism
ADAM-9 quantitative real-time PCR expression analysis Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens potential ADAM-9 sheddase substrates include growth factors and cytokines, which have been linked to atherosclerosis ?
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
aorta
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 Homo sapiens
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artery carotid and femoral arteries, only weak ADAM-9 expression from thyroid artery without atherosclerosis Homo sapiens
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macrophage in advanced human atherosclerotic plaques of aorta and carotid and femoral arteries, high expression level Homo sapiens
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additional information ADAM-9 quantitative real-time PCR expression analysis Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information potential ADAM-9 sheddase substrates include growth factors and cytokines, which have been linked to atherosclerosis Homo sapiens ?
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 ?
additional information ADAM-9 is capable of binding to alpha6beta1 and alphanubeta5 integrins Homo sapiens ?
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 ?

Synonyms

Synonyms Comment Organism
ADAM-9
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 Homo sapiens
ADAM-9 sheddase
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 Homo sapiens

General Information

General Information Comment Organism
physiological function ADAM-9 interaction with alpha6beta1 integrin regulates fibroblast motility, and alpha6beta1 integrin can induce the mobility of several cell types including macrophages. ADAM-9 is involved in advanced human atherosclerosis and might play roles in the monocyte homing, migration, or proliferation in aorta, carotid, and femoral arteries. ADAM-9 is also involved both in ectodomain shedding and cell interactions through integrin binding. Potential ADAM-9 sheddase substrates include growth factors and cytokines, which are linked to atherosclerosis Homo sapiens