Literature summary for 3.4.24.B9 extracted from

Mazzocca, A.; Coppari, R.; De Franco, R.; Cho, J.; Libermann, T.A.; Pinzani, M.; Toker, A.
A secreted form of ADAM9 promotes carcinoma invasion through tumor-stromal interactions (2005), Cancer Res., 65, 4728-4738.

Search for more literature for 3.4.24.B9

Application

Application	Comment	Organism
medicine	secreted form of enzyme promotes carcinoma invasion through tumor-stromal interactions	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
additional information	enzyme expression in tumor cell lines induces a highly invasive phenotype, protease activity of enzyme is required for invasion	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
hepatic stellate cell	cells secrete a alternatively spliced variant of enzyme promoting carcinoma invasion	Homo sapiens	-
myofibroblast	stromal liver myofibroblast, enzyme expression particularly by cells localized within the tumor stroma at the invasive front	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
Laminin + H2O	substrate of secreted form of enzyme	Homo sapiens	?	-	?

Subunits

Subunits	Comment	Organism
More	enzyme binds directly to alpha6beta4 and alpha2beta1 integrins through the disintegrin domain	Homo sapiens

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Release 2023.1 (January 2023)