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Literature summary for 3.4.24.B9 extracted from
- ADAM-9 (MDC-9/meltrin-gamma), a member of the a disintegrin and metalloproteinase family, regulates myeloma-cell-induced interleukin-6 production in osteoblasts by direct interaction with the alpha(v)beta5 integrin (2006), Blood, 107, 3271-3278.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | significantly higher level of enzyme expression in malignant plasma cells than in other cell populations present in bone marrow | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | associated to membrane | Homo sapiens | 16020 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| ARH-77 cell | lymphoblastoid cell | Homo sapiens | - |
| HS Sultan cell | lymphoblastoid cell | Homo sapiens | - |
| osteoblast | recombinant enzyme promotes a fivefold increase in interleukin IL-6, but not IL-1beta mRNA. Enzyme binds directly to alphabeta5 integrin | Homo sapiens | - |
| RPMI-8226 cell | myeloma cell | Homo sapiens | - |
| U-266 cell | myeloma cell | Homo sapiens | - |
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Release 2023.1 (January 2023)
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