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Literature summary for 3.4.24.B9 extracted from

  • Zhou, M.; Graham, R.; Russell, G.; Croucher, P.I.
    MDC-9 (ADAM-9/Meltrin gamma) functions as an adhesion molecule by binding the alpha(v)beta(5) integrin (2001), Biochem. Biophys. Res. Commun., 280, 574-580.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression of GST-enzyme disintegrin domain fusion protein Escherichia coli strain BL21 Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information construction of a GST-enzyme disintegrin domain fusion protein Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information interaction of the enzyme with integrins is inhibited by antibodies against the alphaVbeta5-domain of integrin Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
additional information interaction of the enzyme with integrins is dependent on Ca2+ or Mn2+ Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the enzyme interacts in a RGD motif-independent manner with the alphaVbeta5-domain of integrins, e.g. on the surface of myeloma but not lymphoblastoid cells, dependent on cations Ca2+ or Mn2+ ?
-
?
proteins + H2O Homo sapiens
-
peptides
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme interacts in a RGD motif-independent manner with the alphaVbeta5-domain of integrins, e.g. on the surface of myeloma but not lymphoblastoid cells, dependent on cations Ca2+ or Mn2+ Homo sapiens ?
-
?
proteins + H2O
-
Homo sapiens peptides
-
?

Synonyms

Synonyms Comment Organism
M12.209 Merops-ID Homo sapiens
MDC-9
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
cell adhesion assay at Homo sapiens