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Literature summary for 3.4.24.B9 extracted from
- MDC-9 (ADAM-9/Meltrin gamma) functions as an adhesion molecule by binding the alpha(v)beta(5) integrin (2001), Biochem. Biophys. Res. Commun., 280, 574-580.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression of GST-enzyme disintegrin domain fusion protein Escherichia coli strain BL21 | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | construction of a GST-enzyme disintegrin domain fusion protein | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | interaction of the enzyme with integrins is inhibited by antibodies against the alphaVbeta5-domain of integrin | Homo sapiens |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| additional information | interaction of the enzyme with integrins is dependent on Ca2+ or Mn2+ | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | the enzyme interacts in a RGD motif-independent manner with the alphaVbeta5-domain of integrins, e.g. on the surface of myeloma but not lymphoblastoid cells, dependent on cations Ca2+ or Mn2+ | ? | - |
? |  |
| proteins + H2O | Homo sapiens | - |
peptides | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | the enzyme interacts in a RGD motif-independent manner with the alphaVbeta5-domain of integrins, e.g. on the surface of myeloma but not lymphoblastoid cells, dependent on cations Ca2+ or Mn2+ | Homo sapiens | ? | - |
? | |
| proteins + H2O | - |
Homo sapiens | peptides | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| M12.209 | Merops-ID | Homo sapiens |
| MDC-9 | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
cell adhesion assay at | Homo sapiens |
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Release 2023.1 (January 2023)
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