Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
hair follicle | in intact skin MMP-26 is expressed only in hair follicles | Homo sapiens | - |
keratinocyte | matrilysin-2 (matrix metalloproteinase-26) is upregulated in keratinocytes during wound repair and early skin carcinogenesis. MMP-26 is expressed by laminin-5-positive keratinocytes in the migrating area during wound repair, in benign skin disorders characterized by inflammation and microdisruptions of basement membrane. MMP-26 may be upregulated in basal keratinocytes even without tumorigenesis because of altered cell-matrix interactions and inflammation | Homo sapiens | - |
squamous cell carcinoma cell | MMP-26 is expressed in grade I and II squamous cell cancer. It is not present in dedifferentiated grade III tumors. MMP-26 becomes downregulated during histological dedifferentiation of squamous cell cancer cells | Homo sapiens | - |