Cloned (Comment) | Organism |
---|---|
DNA and amino acid sequence determination and analysis, chromosome mapping to 11p15.3, expression of the enzymes catalytic domain in Escherichia coli BL21 (DE3) | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
hydroxamate inhibitors | - |
Homo sapiens | |
matrix metalloproteinase inhibitor GM6001 | - |
Homo sapiens | |
matrix metalloproteinase inhibitor TIMP-1 | - |
Homo sapiens | |
matrix metalloproteinase inhibitor TIMP-2 | - |
Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
proteins + H2O | Homo sapiens | enzyme plays an important specific role in tumor progression and angiogenesis | peptides | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9NRE1 | - |
- |
Purification (Comment) | Organism |
---|---|
recombinant catalytic domain from inclusion bodies expressed in Escherichia coli | Homo sapiens |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
proteolytic degradation of proteins | consensus cleavage sequence is Pro-Glu-Xaa/Leu-Xaa-Thr-Xaa | Homo sapiens |
Renatured (Comment) | Organism |
---|---|
refolding of recombinant catalytic domain from inclusion bodies expressed in Escherichia coli | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | fetal, gene expression | Homo sapiens | - |
breast carcinoma cell | gene expression | Homo sapiens | - |
colon | decending and transverse, gene expression | Homo sapiens | - |
kidney | adult and fetal, gene expression | Homo sapiens | - |
leukocyte | of peripheral blood, gene expression | Homo sapiens | - |
lung cancer cell | gene expression | Homo sapiens | - |
prostate | gene expression | Homo sapiens | - |
prostate cancer cell | gene expression | Homo sapiens | - |
skeletal muscle | fetal, gene expression | Homo sapiens | - |
small intestine | gene expression | Homo sapiens | - |
spleen | gene expression | Homo sapiens | - |
testis | gene expression | Homo sapiens | - |
thymus | fetal, gene expression | Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
- |
Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(7-methoxycoumarin-4-yl)acetyl-PKPLAL-Dpa-AR-NH2 + H2O | synthetic fluorogenic peptide, catalytic domain of the enzyme | Homo sapiens | ? | - |
? | |
(7-methoxycoumarin-4-yl)acetyl-PLGL-Dpa-AR-NH2 + H2O | synthetic fluorogenic peptide, derived from the catalytic domain of the enzyme | Homo sapiens | ? | - |
? | |
(7-methoxycoumarin-4-yl)acetyl-RPKPVA-norvaline-WMK-(2,4-dinitrophenyl)-NH2 + H2O | synthetic fluorogenic peptide, catalytic domain of the enzyme | Homo sapiens | ? | - |
? | |
(7-methoxycoumarin-4-yl)acetyl-RPKPYA-norvaline-WMK-(2,4-dinitrophenyl)-NH2 + H2O | synthetic fluorogenic peptide, catalytic domain of the enzyme | Homo sapiens | ? | - |
? | |
denatured collagen + H2O | - |
Homo sapiens | ? | - |
? | |
Fibrinogen + H2O | complete degradation, cleavage sequenced of the peptide chains, overview | Homo sapiens | ? | - |
? | |
Fibronectin + H2O | cleavage sequence is PVA44-V45SQS | Homo sapiens | ? | - |
? | |
proteins + H2O | wide substrate specificity | Homo sapiens | peptides | - |
? | |
proteins + H2O | enzyme plays an important specific role in tumor progression and angiogenesis | Homo sapiens | peptides | - |
? | |
Vitronectin + H2O | complete degradation, cleavage sequence is PPEG134-I135DSR | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
M10.029 | Merops-ID | Homo sapiens |
matrix metalloproteinase-26 | - |
Homo sapiens |
MMP-26 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at, except for the assay with collagen as substrate at 25°C | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6.8 | - |
assay at | Homo sapiens |