Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | P57748 | - |
- |
Source Tissue | Comment | Organism | Textmining |
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Organism | Comment | Expression |
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Mus musculus | Mmp20 expression levels must be within a specific range for normal enamel development to occur. Creation of a normally thick enamel layer may occur over a wider range of Mmp20 expression levels, but acquisition of normal enamel hardness has a narrower range | additional information |
General Information | Comment | Organism |
---|---|---|
physiological function | Mmp20 expression levels must be within a specific range for normal enamel development to occur. Creation of a normally thick enamel layer may occur over a wider range of Mmp20 expression levels, but acquisition of normal enamel hardness has a narrower range. Over-expression of Mmp20 results in decreased enamel hardness, this suggests that a balance exists between cleaved and full-length enamel matrix proteins that are essential for formation of a properly hardened enamel layer. High and medium expressing Mmp20 transgenes in a Mmp20 null background have significantly harder and more mineralized enamel than do low transgene expressers. When the high and medium expressing Mmp20 transgenes are present in the wild-type background, the enamel is significantly less well mineralized than normal | Mus musculus |