Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.24.B6 extracted from

  • Bartlett, J.D.; Yamakoshi, Y.; Simmer, J.P.; Nanci, A.; Smith, C.E.
    MMP20 cleaves E-cadherin and influences ameloblast development (2011), Cells Tissues Organs, 194, 222-226.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.B6

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
amelogenin + H2O Mus musculus
-
 ?
-
 ?
E-cadherin + H2O Sus scrofa MMP20 cleaves the extracellular domain of E-cadherin ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-
Sus scrofa
-
-
-

Purification (Commentary)

Purification (Comment) Organism
Q-Sepharose column chromatography and heparin Sepharose 6 column chromatography Mus musculus
Q-Sepharose column chromatography and heparin Sepharose 6 column chromatography Sus scrofa

Source Tissue

Source Tissue Comment Organism Textmining
ameloblast
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
amelogenin + H2O
-
 Mus musculus ?
-
 ?
E-cadherin + H2O MMP20 cleaves the extracellular domain of E-cadherin Sus scrofa ?
-
 ?

Synonyms

Synonyms Comment Organism
MMP20
-
 Mus musculus
MMP20
-
 Sus scrofa

General Information

General Information Comment Organism
malfunction Mmp20-deficient mouse ameloblasts can initiate, terminate, and reinitiate the secretory stage of enamel development Mus musculus
physiological function MMP20 is required for proper enamel formation. MMP20 influences ameloblast developmental progression through hydrolysis of cadherin extracellular domains with associated release of transcription factor(s) Mus musculus
physiological function MMP20 is required for proper enamel formation. MMP20 influences ameloblast developmental progression through hydrolysis of cadherin extracellular domains with associated release of transcription factor(s) Sus scrofa