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Literature summary for 3.4.24.B5 extracted from

  • Majali-Martinez, A.; Velicky, P.; Pollheimer, J.; Knoefler, M.; Yung, H.W.; Burton, G.J.; Tabrizi-Wizsy, N.G.; Lang, U.; Hiden, U.; Desoye, G.; Dieber-Rotheneder, M.
    Endothelin-1 down-regulates matrix metalloproteinase 14 and 15 expression in human first trimester trophoblasts via endothelin receptor type B (2017), Hum. Reprod., 32, 46-54 .
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
gene MMP15, quantitative RT-PCR enzyme expression analysis Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ a zinc-dependent endopeptidase Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P51511
-
-

Source Tissue

Source Tissue Comment Organism Textmining
placenta
-
 Homo sapiens
-
trophoblast primary human trophoblasts from 50 first trimester placentas (gestational week 7-12), high MMP115 expression Homo sapiens
-

Synonyms

Synonyms Comment Organism
matrix metalloproteinase 15
-
 Homo sapiens
MMP15
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens endothelin-1 (ET-1) downregulates matrix metalloproteinase 15 expression in human first trimester trophoblasts via endothelin receptor type B (ETRB). ET-1 downregulates MMP15 mRNA and protein levels. TNF-alpha enhances ET-1-mediated MMP15 downregulation in primary trophoblasts down

General Information

General Information Comment Organism
metabolism MMP14 and MMP15 are involved in trophoblast invasion Homo sapiens