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Literature summary for 3.4.24.B5 extracted from
- Membrane-type-2 matrix metalloproteinase can initiate the processing of progelatinase A and is regulated by the tissue inhibitors of metalloproteinases (1997), Eur. J. Biochem., 244, 653-657.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression of the enzymes catalytic domain in Escherichia coli | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | no inhibition by tissue matrix metalloproteinase inhibitor TIMP-1 | Homo sapiens | |
| tissue matrix metalloproteinase inhibitor TIMP-2 | - |
Homo sapiens | |
| tissue matrix metalloproteinase inhibitor TIMP-3 | - |
Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | on the cell surface | Homo sapiens | 16020 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| matrix metalloproteinase progelatinase A + H2O | Homo sapiens | substrate is activated by cleavage | matrix metalloproteinase gelatinase A | - |
? |  |
| protein + H2O | Homo sapiens | - |
peptides | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
membrane-type-2 matrix metalloprotease | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (7-methoxycoumarin-4-yl)acetyl-Pro-Leu-Gly-Leu-[3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl]-Ala-Arg-NH2 + H2O | synthetic fluorogenic substrate | Homo sapiens | ? | - |
? | |
| matrix metalloproteinase progelatinase A + H2O | substrate is activated by cleavage | Homo sapiens | matrix metalloproteinase gelatinase A | - |
? | |
| progelatinase A + H2O | substrate is activated by cleavage | Homo sapiens | gelatinase A + ? | - |
? | |
| protein + H2O | - |
Homo sapiens | peptides | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| M10.015 | Merops-ID | Homo sapiens |
| membrane-type-2 matrix metalloproteinase | - |
Homo sapiens |
| MT2 MMP | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
assay at | Homo sapiens |
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Release 2023.1 (January 2023)
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