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Literature summary for 3.4.24.B4 extracted from

  • Meierjohann, S.; Hufnagel, A.; Wende, E.; Kleinschmidt, M.A.; Wolf, K.; Friedl, P.; Gaubatz, S.; Schartl, M.
    MMP13 mediates cell cycle progression in melanocytes and melanoma cells: in vitro studies of migration and proliferation (2010), Mol. Cancer, 9, 201.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.B4

Inhibitors

Inhibitors Comment Organism Structure
CL 82198 specific inhibitor Homo sapiens
CL 82198 specific inhibitor Mus musculus

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
A-375 cell
-
 Homo sapiens
-
melan-a Hm cell
-
 Mus musculus
-
melanocyte
-
 Mus musculus
-
melanocyte
-
 Homo sapiens
-
melanoma cell
-
 Mus musculus
-
melanoma cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Gelatin + H2O
-
 Mus musculus ?
-
 ?
Gelatin + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
MMP13
-
 Mus musculus
MMP13
-
 Homo sapiens

Expression

Organism Comment Expression
Mus musculus after epidermal growth factor stimulation MMP13 is up-regulated up
Homo sapiens after epidermal growth factor stimulation MMP13 is up-regulated up

General Information

General Information Comment Organism
malfunction knockdown of MMP13 strongly enhances pigmentation of melanocytes Mus musculus
malfunction knockdown of MMP13 strongly enhances pigmentation of melanocytes Homo sapiens
physiological function MMP13 mediates cell proliferation in melanocytes and melanoma cells. Growth stimuli are mediated via MMP13 in melanocytes and melanoma Mus musculus
physiological function MMP13 mediates cell proliferation in melanocytes and melanoma cells. Growth stimuli are mediated via MMP13 in melanocytes and melanoma Homo sapiens