Literature summary for 3.4.24.B4 extracted from

Im, H.; Sharrocks, A.; Lin, X.; Yan, D.; Kim, J.; Van Wijnen, A.; Hipskind, R.
Basic fibroblast growth factor induces matrix metalloproteinase-13 via eRK MAP kinase-altered phosphorylation and sumoylation of Elk-1 in human adult articular chondrocytes (2009), Open Access Rheumatol., 1, 151-161.

Search for more literature for 3.4.24.B4

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
extracellular matrix	-	Homo sapiens	31012	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
chondrocyte	articular	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
MMP-13	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	the bFGF-ERK-Elk-1 signaling axis is responsible for the potent induction of MMP-13 in primary articular chondrocytes. Phosphorylation renders Elk-1 competent for induction of MMP-13 gene transcription, while sumoylation has the opposite effect. Unphosphorylatable Elk-1 S383A mutant and unphosphorylated Elk-1 are inactive, while mutation of the SUMO modification site of Elk-1 to GAL4-Elk-1K230R/K249R increases its activity. bFGF-mediated activation of Elk-1 is regulated by the SUMO pathway	up

General Information

General Information	Comment	Organism
additional information	in addition to phosphorylation of Elk-1, dynamic posttranslational modification of Elk-1 by small ubiquitin-related modifier, SUMO, serves as an important mechanism through which MMP-13 gene expression is regulated	Homo sapiens

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Release 2023.1 (January 2023)