Application | Comment | Organism |
---|---|---|
drug development | the enzyme is a target for design of tetracycline-based drugs | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
minocycline | inhibits MMP-13 activity in synoviocytes | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cartilage | - |
Homo sapiens | - |
synoviocyte | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
MMP-13 | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | doxycycline decreases MMP-13 expression in synoviocytes but not cartilage | down |
General Information | Comment | Organism |
---|---|---|
additional information | protective effects of tetracycline compounds are more pronounced in synoviocytes than cartilage, and following minocycline compared to doxycycline, molecular mechanism of action, overview | Homo sapiens |