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Literature summary for 3.4.24.B4 extracted from

  • Fortier, L.A.; Motta, T.; Greenwald, R.A.; Divers, T.J.; Mayr, K.G.
    Synoviocytes are more sensitive than cartilage to the effects of minocycline and doxycycline on IL-1alpha and MMP-13-induced catabolic gene responses (2010), J. Orthop. Res., 28, 522-528.
    View publication on PubMed

Application

Application Comment Organism
drug development the enzyme is a target for design of tetracycline-based drugs Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
minocycline inhibits MMP-13 activity in synoviocytes Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
cartilage
-
Homo sapiens
-
synoviocyte
-
Homo sapiens
-

Synonyms

Synonyms Comment Organism
MMP-13
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens doxycycline decreases MMP-13 expression in synoviocytes but not cartilage down

General Information

General Information Comment Organism
additional information protective effects of tetracycline compounds are more pronounced in synoviocytes than cartilage, and following minocycline compared to doxycycline, molecular mechanism of action, overview Homo sapiens