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Literature summary for 3.4.24.B4 extracted from

  • Blaney Davidson, E.N.; Remst, D.F.; Vitters, E.L.; van Beuningen, H.M.; Blom, A.B.; Goumans, M.J.; van den Berg, W.B.; van der Kraan, P.M.
    Increase in ALK1/ALK5 ratio as a cause for elevated MMP-13 expression in osteoarthritis in humans and mice (2009), J. Immunol., 182, 7937-7945.
    View publication on PubMed
Search for more literature for 3.4.24.B4

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular matrix
-
 Mus musculus 31012
-
extracellular matrix
-
 Homo sapiens 31012
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
type II collagen + H2O Mus musculus
-
 ?
-
 ?
type II collagen + H2O Homo sapiens
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
 male C57BL/6N mice and STR/ort mice
-

Source Tissue

Source Tissue Comment Organism Textmining
cartilage
-
 Mus musculus
-
cartilage
-
 Homo sapiens
-
chondrocyte
-
 Mus musculus
-
chondrocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
type II collagen + H2O
-
 Mus musculus ?
-
 ?
type II collagen + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
MMP-13
-
 Mus musculus
MMP-13
-
 Homo sapiens

Expression

Organism Comment Expression
Mus musculus transfection of chondrocytes with adenovirus overexpressing constitutive active ALK1 increased MMP-13 expression, while small interfering RNA against ALK1 decreases MMP-13 expression to nondetectable levels down
Homo sapiens ALK1 stimulates MMP-13 expression in chondrocytes up
Mus musculus transfection of chondrocytes with adenovirus overexpressing constitutive active ALK1 increased MMP-13 expression, while small interfering RNA against ALK1 decreases MMP-13 expression to nondetectable levels up

General Information

General Information Comment Organism
additional information ALK1 and Alk5 are involved in MMP-13 activity regulation, age-related shift in ALK1/ALK5 ratio in murine cartilage. A change in balance between ALK5 and ALK1 receptors in chondrocytes causes changes in MMP-13 expression, thereby causing an osteoarthritis-like phenotype Mus musculus
additional information cartilage ALK1 is highly correlated with MMP-13 expression, whereas ALK5 correlates with aggrecan and collagen type II expression. Strong correlation between ALK1 and MMP-13 expression in human cartilage Homo sapiens